SAB4502546

Anti-BAX antibody produced in rabbit

affinity isolated antibody

• Sinonimo/i: Apoptosis regulator BAX, BAX, BCL2L4, Bcl-2-like protein 4, Bcl2-L-4
• Codice UNSPSC: 12352203
• NACRES: NA.43

Proprietà

• Origine biologica: rabbit
• Coniugato: unconjugated
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Forma fisica: buffered aqueous solution
• PM: antigen 21 kDa
• Reattività contro le specie: rat, human, mouse
• Concentrazione: ~1 mg/mL
• tecniche: ELISA: 1:1000; immunofluorescence: 1:100-1:500; western blot: 1:500-1:1000
• N° accesso NCBI: Q07812
• N° accesso UniProt: Q07812
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... BAX(581)

Descrizione

Descrizione generale

Anti-BAX antibody detects endogenous levels of total BAX protein.

The BAX (BCL2 (B-cell lymphoma 2) associated X, apoptosis regulator) gene is mapped to human chromosome 19q13.33. It codes for α-helical globular protein. The protein contains eight amphipathic helices around a hydrophobic helix. Bax is known to be mostly localized in the cytoplasm.

Immunogeno

The antiserum was produced against synthesized peptide derived from human Bax.

Immunogen Range: 133-182

Applicazioni

Anti-BAX, C-Terminal antibody produced in rabbit has been used in western blotting analysis.

Azioni biochim/fisiol

BAX (BCL2 (B-cell lymphoma 2) associated X, apoptosis regulator) is predominantly associated with cellular homeostasis, cell cycle and pathogenesis of cell death particularly in cancer cells. In response to an apoptotic stimulus, Bax brings about mitochondrial dysfunction and apoptosis. Oligomerization of bax promotes mitochondrial outer membrane permeabilization.

Caratteristiche e vantaggi

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Stato fisico

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): nwg
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable