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S4068

Sigma-Aldrich

Splitomicin

≥98% (HPLC), powder

Sinonimo/i:

1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one

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5 MG
CHF 83.50

CHF 83.50

Spedizione prevista il13 aprile 2025

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5 MG
CHF 83.50

About This Item

Formula empirica (notazione di Hill):
C13H10O2
Numero CAS:
5690-03-9
Peso molecolare:
198.22
Numero MDL:
MFCD08705254
Codice UNSPSC:
12352200
ID PubChem:
24724608
NACRES:
NA.77

CHF 83.50

Spedizione prevista il13 aprile 2025

Richiedi un ordine bulk

Livello qualitativo

100

Saggio

≥98% (HPLC)

Stato

powder

Temperatura di conservazione

2-8°C

Stringa SMILE

O=C1CCc2c(O1)ccc3ccccc23

InChI

1S/C13H10O2/c14-13-8-6-11-10-4-2-1-3-9(10)5-7-12(11)15-13/h1-5,7H,6,8H2
ISFPDBUKMJDAJH-UHFFFAOYSA-N

Applicazioni

Splitomicin was used to inhibit SIRT1 in human aortic endothelial cells[1][2] and sirtuins in human breast cancer cells.[3] Mouse leukaemic monocyte macrophage cell line was treated with Splitomicin prior to cholesterol efflux studies.[4]

Azioni biochim/fisiol

Sir2p (silent information regulator) and HDAC inhibitor.
Splitomicin, a derivative of β-naphthol is an inhibitor of Silent Information Regulator 2 (SIR2). It inhibits the NAD+-dependent deacetylase activity of Sir2 in vitro.[5] It increases the levels of cyclic AMP by inhibiting the activity of cyclic AMP phosphodiesterase, interferes with mobilization of intracellular Ca+2 and ATP release. This results in inhibition of platelet aggregation that is effective in cardiovascular and cerebrovascular diseases.[6]

Caratteristiche e vantaggi

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Prodotti correlati

N° Catalogo
Descrizione
Determinazione del prezzo

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
0000221877
057M4721V
064M4709V
061M4609V
038K46093

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Gil Blander et al.
Annual review of biochemistry, 73, 417-435 (2004-06-11)
The yeast SIR protein complex has been implicated in transcription silencing and suppression of recombination. The Sir complex represses transcription at telomeres, mating-type loci, and ribosomal DNA. Unlike SIR3 and SIR4, the SIR2 gene is highly conserved in organisms ranging
Fu-Chao Liu et al.
Thrombosis research, 124(2), 199-207 (2009-03-31)
Splitomicin is derived from beta-naphthol and is an inhibitor of Silent Information Regulator 2 (SIR2). Its naphthoic moiety might be responsible for its inhibitory effects on platelets. The major goal of our study was to examine possible mechanisms of action
Evi X Stavrou et al.
Blood, 125(4), 710-719 (2014-10-24)
The precise mechanism for reduced thrombosis in prekallikrein null mice (Klkb1(-/-)) is unknown. Klkb1(-/-) mice have delayed carotid artery occlusion times on the rose bengal and ferric chloride thrombosis models. Klkb1(-/-) plasmas have long-activated partial thromboplastin times and defective contact
Hestia S Mellert et al.
The Journal of biological chemistry, 286(6), 4264-4270 (2010-12-15)
In unstressed cells, the p53 tumor suppressor is highly unstable. DNA damage and other forms of cellular stress rapidly stabilize and activate p53. This process is regulated by a complex array of post-translational modifications that are dynamically deposited onto p53.
Niannian Yang et al.
Molecular medicine reports, 22(5), 3695-3704 (2020-10-02)
Epithelial-to-mesenchymal transition (EMT) in nasal epithelial cells is involved with tissue remodeling of nasal polyps. The present study investigated the molecular mechanisms through which miR‑155‑5p regulated EMT in chronic rhinosinusitis (CRS). Patients were divided into the following groups: CRSsNP, CRS
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