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Merck
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76904

Sigma-Aldrich

Vecuronium bromide

Sinonimo/i:

1-[(2β,3α,5α,16β,17β)-3,17-Bis(acetyloxy)-2-(1-piperidinyl)androstan-16-yl]-1-methyl-piperidinium bromide

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About This Item

Formula empirica (notazione di Hill):
C34H57BrN2O4
Numero CAS:
50700-72-6
Peso molecolare:
637.73
Beilstein:
4837308
Numero CE:
256-723-9
Numero MDL:
MFCD00867762
Codice UNSPSC:
51152000
ID PubChem:
329767429
NACRES:
NA.77

Origine biologica

synthetic

Saggio

≥97.0% (TLC)

Forma fisica

powder or crystals

Gruppo funzionale

carboxylic acid

Stringa SMILE

[Br-].CC(=O)O[C@H]1C[C@@H]2CC[C@@H]3[C@H](CC[C@@]4(C)[C@H]3C[C@@H]([C@@H]4OC(C)=O)[N+]5(C)CCCCC5)[C@@]2(C)C[C@@H]1N6CCCCC6

InChI

1S/C34H57N2O4.BrH/c1-23(37)39-31-20-25-12-13-26-27(34(25,4)22-29(31)35-16-8-6-9-17-35)14-15-33(3)28(26)21-30(32(33)40-24(2)38)36(5)18-10-7-11-19-36;/h25-32H,6-22H2,1-5H3;1H/q+1;/p-1/t25-,26+,27-,28-,29-,30-,31-,32-,33-,34-;/m0./s1
VEPSYABRBFXYIB-PWXDFCLTSA-M

Informazioni sul gene

human ... CHRNA1(1134) , CHRNB1(1140) , CHRND(1144) , CHRNE(1145) , CHRNG(1146)

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Categorie correlate

Azioni biochim/fisiol

Vecuronium Bromide is an aminosteroidal neuromuscular blocking agent. It relaxes the skeletal muscle and decreases oxygen consumption during surgery. It competes with acetylcholine and bind to cholinergic receptors at neuromuscular junctions.

Confezionamento

Bottomless glass bottle. Contents are inside inserted fused cone.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302

Classi di pericolo

Acute Tox. 4 Oral

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificati d'analisi (COA)

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Fosfato di potassio for molecular biology, ≥98.0%

Sigma-Aldrich

P9791

Fosfato di potassio

Hong WANG et al.
Acta pharmacologica Sinica, 31(12), 1541-1546 (2010-11-26)
to investigate the changing resistance to nondepolarizing muscle relaxants (NDMRs) during the first month after denervation. the denervated and innervated skeletal muscle cells were examined on days 1, 4, 7, 14, 21, and 28 after denervation. Individual denervated and innervated
Shawn P Vorce et al.
Journal of analytical toxicology, 32(6), 422-427 (2008-07-26)
The apparent recreational use of an aminosteroidal non-depolarizing neuromuscular blocking agent, vecuronium, is reported in this postmortem investigation. A quantitative method for the analysis of vecuronium and its active metabolite, 3-desacetylvecuronium, in blood and tissue samples was developed using liquid
Hong Wang et al.
Acta pharmacologica Sinica, 32(12), 1454-1459 (2011-10-12)
To investigate the effect of magnesium sulfate and its interaction with the non-depolarizing muscle relaxant vecuronium at adult muscle-type acetylcholine receptors in vitro. Adult muscle-type acetylcholine receptors were expressed in HEK293 cells. Drug-containing solution was applied via a gravity-driven perfusion
K R Vega-Villa et al.
British journal of anaesthesia, 112(2), 304-310 (2013-09-27)
Burn patients develop resistance to non-depolarizing neuromuscular blocking agents (NDNMBAs) and require a significantly large dose to produce a desired clinical response. Pathophysiological changes related to burn injury may alter pharmacokinetics (PK) and pharmacodynamics of NDNMBAs. The purpose of this
W C Bowman
British journal of pharmacology, 147 Suppl 1, S277-S286 (2006-01-13)
Descriptions of the South American arrow poisons known as curares were reported by explorers in the 16th century, and their site of action in producing neuromuscular block was determined by Claude Bernard in the mid-19th century. Tubocurarine, the most important
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