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B5887

Sigma-Aldrich

Sodium butyrate

≥98.5% (GC)

Sinonimo/i:

Butyric acid sodium salt

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250 MG
CHF 93.40
1 G
CHF 282.00
5 G
CHF 1’000.00

CHF 93.40

Spedizione prevista il31 marzo 2025

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Cambia visualizzazione
250 MG
CHF 93.40
1 G
CHF 282.00
5 G
CHF 1’000.00

About This Item

Formula condensata:
CH3CH2CH2COONa
Numero CAS:
156-54-7
Peso molecolare:
110.09
Beilstein:
3629439
Numero CE:
205-857-6
Numero MDL:
MFCD00002816
Codice UNSPSC:
12352107
ID PubChem:
24891873
NACRES:
NA.25

CHF 93.40

Spedizione prevista il31 marzo 2025

Richiedi un ordine bulk

Origine biologica

synthetic (organic)

Livello qualitativo

200

Saggio

≥98.5% (GC)

Stato

powder

Condizioni di stoccaggio

(Tightly closed. Dry.
Keep in a dry place. )

tecniche

DNA amplification: suitable
cell based assay: suitable
inhibition assay: suitable

Colore

white

Punto di fusione

250-253 °C (lit.)

Solubilità

water: 100 mg/mL, clear to slightly hazy, colorless

Cationi in tracce

Na: 19.8-22.0% (anhydrous)

Compatibilità

suitable for DNA precipitation

applicazioni

cell analysis
life science and biopharma
lipidomics

Temperatura di conservazione

room temp

Stringa SMILE

[Na+].CCCC([O-])=O

InChI

1S/C4H8O2.Na/c1-2-3-4(5)6;/h2-3H2,1H3,(H,5,6);/q;+1/p-1
MFBOGIVSZKQAPD-UHFFFAOYSA-M

Informazioni sul gene

mouse ... ENSMUSG00000061062(15181)

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Applicazioni

Sodium butyrate has been used:
  • as a component in homogenization and immunoprecipitation buffer for HDAC inhibition in fly embryos and insect s2 cells.[1]
  • as histone deacetylase inhibitor in breast cancer cell line MDA-MB-231, analysed by cell viability assay and viral replication assay.[2]
  • to enhance the production of recombinant tissue-plasminogen activator (t-PA) in Chinese hamster ovary (CHO) cells in a bioreactor.[3]

Azioni biochim/fisiol

Sodium butyrate is a short-chain fatty acid that inhibits histone deacetylase (HDAC) in the millimolar range.[1][2] Decreases Ca2+ release from intracellular stores. Induces apoptosis in several cell lines. Sodium butyrate induces the production of recombinant protein in Chinese hamster ovary (CHO) cells and other human cell lines. Sodium butyrate affects the proteome and gene expression pathways in the cells. It represses cell cycle related genes and modifies the genes involved in cell metabolism and apoptosis.[3]

Avvertenza

Hygroscopic

Altre note

For additional information on our range of Biochemicals, please complete this form.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302,H315,H319

Classi di pericolo

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
0000408364
0000408364
0000407728
0000407727
0000407728

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Histone deacetylase inhibitors improve the replication of oncolytic herpes simplex virus in breast cancer cells
Cody JJ, et al.
PLoS ONE, 9(3), e92919-e92919 (2014)
Histone deacetylase Rpd3 regulates olfactory projection neuron dendrite targeting via the transcription factor Prospero
Tea JS, et al.
The Journal of Neuroscience, 30(29), 9939-9946 (2010)
Na-butyrate sustains energetic states of metabolism and t-PA productivity of CHO cells
McMurray-Beaulieu V, et al.
Journal of Bioscience and Bioengineering, 108(2), 160-167 (2009)
Jiangping He et al.
Nature communications, 10(1), 34-34 (2019-01-04)
The majority of mammalian genomes are devoted to transposable elements (TEs). Whilst TEs are increasingly recognized for their important biological functions, they are a potential danger to genomic stability and are carefully regulated by the epigenetic system. However, the full
Ras Trokovic et al.
Stem cell research, 15(1), 254-262 (2015-06-23)
Somatic cells can be reprogrammed into induced pluripotent stem cells (iPSC) by the forced expression of the transcription factors OCT4, SOX2, KLF4 and c-MYC. Pluripotent reprogramming appears as a slow and inefficient process because of genetic and epigenetic barriers of
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Questions

1–3 of 3 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. I would like to know which is the recommended solvent to make dilutions with Sodium butyrate B5887, they are meant for long-term storage.

    1 answer

    1. This product is soluble in water at 100 mg/mL. The filter-sterilized solution is stable for up to 2 years at 2-8°C as indicated for the 500mM prepared solution, product TR-1008.

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