72340

Nicotinamide

≥99.5% (HPLC)

• Sinonimo/i: Niacinamide, Nicotinic acid amide, Pyridine-3-carboxylic acid amide, Vitamin B₃, Vitamin PP
• Formula empirica (notazione di Hill): C₆H₆N₂O
• Numero CAS: 98-92-0
• Peso molecolare: 122.12
• Beilstein: 383619
• Numero CE: 202-713-4
• Numero MDL: MFCD00006395
• Codice UNSPSC: 12352205
• ID PubChem: 57652413
• NACRES: NA.79

Proprietà

• Origine biologica: synthetic
• Livello qualitativo: 200
• Saggio: ≥99.5% (HPLC)
• Stato: powder or crystals
• Residuo alla calcinazione: ≤0.2%
• Perdita: ≤0.2% loss on drying, 20 °C (HV)
• Colore: colorless to white
• Punto di fusione: 128-131 °C (lit.); 128-131 °C
• Anioni in tracce: chloride (Cl^-): ≤50 mg/kg; sulfate (SO₄^2-): ≤150 mg/kg
• Cationi in tracce: Ca: ≤10 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: ≤5 mg/kg; Fe: ≤5 mg/kg; K: ≤50 mg/kg; Mg: ≤5 mg/kg; Mn: ≤5 mg/kg; Na: ≤50 mg/kg; Ni: ≤5 mg/kg; Pb: ≤5 mg/kg; Zn: ≤5 mg/kg
• applicazioni: cell analysis
• Stringa SMILE: NC(=O)c1cccnc1
• InChI: 1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9); DFPAKSUCGFBDDF-UHFFFAOYSA-N
• Informazioni sul gene: human ... PARP1(142) , SIRT2(22933)

Descrizione

Descrizione generale

Nicotinamide, a form of vitamin B3, is a building block of coenzymes NAD and NADP. Researchers consider it an important signaling molecule, and essential for cell metabolism studies. It has been used in multiple applications and research areas, namely cancer and viral research.

Applicazioni

Nicotinamide has been used:

• to study its effect on the expression of sirtuin 1[1]
• in nicotinamide adenine dinucleotide/nicotinamide adenine dinucleotide phopshate (NAD+/NADH) cycling assay[2]
• in cell lysis buffer, to serve as a sirtuin 1 inhibitor in order to study its role in resveratrol (RSV)-stimulated hepatitis B virus replication[3]

Azioni biochim/fisiol

Nicotinamide (Niacinamide) (Nam) is a building block (active component) of coenzymes nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phopshate (NADP). Nicotinamide may be used as a substrate of nicotinamide phosphoribosyltransferase (NAMPT, EC 2.4.2.12), the rate-limiting enzyme for NAD(+) biosynthesis and an important signaling molecule.

Nicotinamide is an amide derivative of vitamin B3 and a PARP inhibitor

The coenzymes NAD and NADP take part in energy yielding metabolism and mediate several oxidation-reduction reactions. NAD hydrolyses to form nicotinamide, which is then transported to other tissues.[4] Hydrolysis of nicotinamide yields nicotinic acid through salvage pathway.[5]

Altre note

Coenzymes and Cofactors, vol. 2: Pyridine Nucleotide Coenzymes[6][7]

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H319
• Consigli di prudenza: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Classi di pericolo: Eye Irrit. 2
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): 302.0 °F - closed cup
• Punto d’infiammabilità (°C): 150 °C - closed cup
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves