PZ0171

CP-100356 monohydrochloride

>98% (HPLC), powder, MDR1 (P-Gp) inhibitor

• Sinonimo/i: 4-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-6,7-dimethoxy-2-quinazolinamine monohydrochloride
• Formula empirica (notazione di Hill): C₃₁H₃₆N₄O₆ · HCl
• Numero CAS: 142715-48-8
• Peso molecolare: 597.10
• Numero MDL: MFCD00911858
• Codice UNSPSC: 12161501
• ID PubChem: 329823745
• NACRES: NA.77

Proprietà

• product name: CP-100356 monohydrochloride, >98% (HPLC)
• Saggio: >98% (HPLC)
• Forma fisica: powder
• Condizioni di stoccaggio: desiccated
• Colore: white to off-white
• Solubilità: DMSO: >5 mg/mL
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: Cl.COc1ccc(CCNc2nc(N3CCc4cc(OC)c(OC)cc4C3)c5cc(OC)c(OC)cc5n2)cc1OC
• InChI: 1S/C31H36N4O6.ClH/c1-36-24-8-7-19(13-25(24)37-2)9-11-32-31-33-23-17-29(41-6)28(40-5)16-22(23)30(34-31)35-12-10-20-14-26(38-3)27(39-4)15-21(20)18-35;/h7-8,13-17H,9-12,18H2,1-6H3,(H,32,33,34);1H; WWCHXVYTCMPAMV-UHFFFAOYSA-N

Descrizione

Azioni biochim/fisiol

CP-100356 is a specific inhibitor of MDR1 (P-Gp), the protypical ABC transporter. The compound has low uM to nM potency for inhibiting several MDR-1 substrates (calcein-AM, digoxin) in transfected MDCKII cells. CP-100356 also inhibits prazosin transport in human breast cancer resistance protein (BCRP)-transfected MDCKII cells, suggesting that it acts as a dual inhibitor. CP-100356 does not inhibit multidrug resistance-associated protein 2 (MPR2 IC₅₀ >15 mM).

Caratteristiche e vantaggi

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Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable