O4000

Oxythiamine chloride hydrochloride

≥95% (HPLC)

• Sinonimo/i: 5-(2-Hydroxyethyl)-3-(4-hydroxy-2-methyl-5-pyrimidinylmethyl)-4-methylthiazolium chloride
• Formula empirica (notazione di Hill): C₁₂H₁₆ClN₃O₂S · HCl
• Numero CAS: 614-05-1
• Peso molecolare: 338.25
• Numero MDL: MFCD00050656
• Codice UNSPSC: 12352116
• ID PubChem: 24897990
• NACRES: NA.79

Proprietà

• Livello qualitativo: 200
• Saggio: ≥95% (HPLC)
• Stato: powder
• tecniche: HPLC: suitable
• Colore: white to off-white
• Temperatura di conservazione: −20°C
• Stringa SMILE: CC(N1)=NC=C(C[N+]2=CSC(CCO)=C2C)C1=O.Cl.[Cl-]
• InChI: 1S/C12H16N3O2S.2ClH/c1-8-11(3-4-16)18-7-15(8)6-10-5-13-9(2)14-12(10)17;;/h5,7,16H,3-4,6H2,1-2H3,(H,13,14,17);2*1H; QHUYPZVMEJLSEB-UHFFFAOYSA-N

Descrizione

Descrizione generale

Oxythiamine is a thiamine antimetabolite and the source through diet is by consuming acidic thiamine rich foods.[1]

Applicazioni

Oxythiamine chloride hydrochloride is suitable for use:

• as a reference standard for calibration curve generation in liquid chromatography-tandem mass spectrometry (LC-MS/MS) for oxythiamine pyrophosphate (OTPP) quantification in red blood cells[2]
• as a thiamine transport inhibitor in human mammary epithelial cells (HMEC) and breast cancer cell lines[3]
• in the synthesis of oxythiamineH picrolonate salt[4]

Azioni biochim/fisiol

Oxythiamine (OT) is a thiamine antagonist.[5] It is a transketolase inhibitor and is employed to study anti-metastatic mechanisms,[5] especially those involving metalloproteinases (MMP).[6] It significantly sensitizes human hepatocellular carcinoma cells (HCC) to sorafenib, favoring tumor suppression.[7]

Oxythiamine inhibits Transketolase, the enzyme that controls the nonoxidative branch of the pentose phosphate pathway.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)