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Merck
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Documenti

A4638

Sigma-Aldrich

Azathioprine

≥98%

Sinonimo/i:

6-(1-Methyl-4-nitroimidazol-5-yl)thiopurine

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About This Item

Formula empirica (notazione di Hill):
C9H7N7O2S
Numero CAS:
446-86-6
Peso molecolare:
277.26
Numero CE:
207-175-4
Numero MDL:
MFCD00069203
Codice UNSPSC:
12352202
ID PubChem:
57653853
NACRES:
NA.77

Origine biologica

synthetic (organic)

Saggio

≥98%

Forma fisica

powder

Solubilità

1 M NH4OH: 20 mg/mL, clear to slightly hazy

Temperatura di conservazione

−20°C

Stringa SMILE

Cn1cnc(c1Sc2ncnc3[nH]cnc23)[N+]([O-])=O

InChI

1S/C9H7N7O2S/c1-15-4-14-7(16(17)18)9(15)19-8-5-6(11-2-10-5)12-3-13-8/h2-4H,1H3,(H,10,11,12,13)
LMEKQMALGUDUQG-UHFFFAOYSA-N

Informazioni sul gene

human ... PPAT(5471)

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Azioni biochim/fisiol

Has shown promise in treatment of alopecia areata (autoimmune hair loss), with no difference in effectiveness between genders.

Pittogrammi

Health hazardExclamation mark
GHS08,GHS07

Avvertenze

Danger

Indicazioni di pericolo

H302,H315,H319,H335,H350,H361fd

Classi di pericolo

Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Mercaptopurine United States Pharmacopeia (USP) Reference Standard

USP

1392002

Mercaptopurine

Metotrexato meets USP testing specifications

Sigma-Aldrich

M9929

Metotrexato

Sulfathiazole

Supelco

S9876

Sulfathiazole

Fludarabine phosphate

Sigma-Aldrich

F9813

Fludarabine phosphate

Sulfasalazine 97.0-101.5%

Sigma-Aldrich

S0883

Sulfasalazine

Prednisolone ≥99%

Sigma-Aldrich

P6004

Prednisolone

Cyclophosphamide monohydrate analytical standard

Supelco

93813

Cyclophosphamide monohydrate

6-Thioguanine ≥98%

Sigma-Aldrich

A4882

6-Thioguanine

Fosfato di sodio BioXtra, for molecular biology, ≥99.5% (T)

Sigma-Aldrich

71507

Fosfato di sodio

Susan Farshi et al.
International journal of dermatology, 49(10), 1188-1193 (2010-10-05)
Alopecia areata is an autoimmune disease resulting in partial or total nonscarring hair loss and the treatment of severe alopecia areata is difficult. The aim of this study was to evaluate the efficacy and safety of azathioprine as a systemic
Systemic therapies for severe atopic dermatitis in children and adults.
Carsten Flohr et al.
The Journal of allergy and clinical immunology, 132(3), 774-774 (2013-09-03)
Loïc Guillevin et al.
The New England journal of medicine, 371(19), 1771-1780 (2014-11-06)
The combination of cyclophosphamide and glucocorticoids leads to remission in most patients with antineutrophil cytoplasm antibody (ANCA)-associated vasculitides. However, even when patients receive maintenance treatment with azathioprine or methotrexate, the relapse rate remains high. Rituximab may help to maintain remission.
Björn Pasternak et al.
American journal of epidemiology, 177(11), 1296-1305 (2013-03-22)
Increased risks of lymphoma and skin cancer associated with thiopurine use among patients with inflammatory bowel disease have been shown, but data on the overall cancer risk are limited. We conducted a historical cohort study of 45,986 patients with inflammatory
Eliza Prefontaine et al.
The Cochrane database of systematic reviews, (6)(6), CD000545-CD000545 (2010-06-18)
The results from controlled clinical trials investigating the efficacy of azathioprine and 6-mercaptopurine for the treatment of active Crohn's disease were conflicting and controversial. A meta-analysis was performed to assess the effectiveness of these drugs for the induction of remission
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