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N8784

Sigma-Aldrich

Norcantharidin

solid

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About This Item

Formula empirica (notazione di Hill):
C8H8O4
Numero CAS:
29745-04-8
Peso molecolare:
168.15
Numero MDL:
MFCD00213361
Codice UNSPSC:
12352202
ID PubChem:
24278599
NACRES:
NA.77

Stato

solid

Stringa SMILE

O=C1OC(=O)C2C3CCC(O3)C12

InChI

1S/C8H8O4/c9-7-5-3-1-2-4(11-3)6(5)8(10)12-7/h3-6H,1-2H2
JAABVEXCGCXWRR-UHFFFAOYSA-N

Informazioni sul gene

human ... PPP2R5A(5525)

Descrizione generale

Norcantharidin (NCTD) is a demethylated derivative of cantharidin (CTD).[1]

Applicazioni

Norcantharidin has been used in primary cell culture and treatment.[2] It has also been used to treat mice inoculated with Huh7 cells subcutaneously.[3]

Azioni biochim/fisiol

Norcantharidin is a potential antitumor agent. Norcantharidin helps to block SK-N-SH neuroblastoma cell growth by stimulating autophagy and apoptosis.[1]

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
101K1371

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Xin-Yuan Ding et al.
International journal of nanomedicine, 7, 1723-1735 (2012-05-24)
A novel formulation containing polyvinylpyrrolidone (PVP) K(30)-coated norcantharidin (NCTD) chitosan nanoparticles (PVP-NCTD-NPs) was prepared by ionic gelation between chitosan and sodium tripolyphosphate. The average particle size of the PVP-NCTD-NPs produced was 140.03 ± 6.23 nm; entrapment efficiency was 56.33% ±
Min Guan et al.
International journal of nanomedicine, 7, 1921-1930 (2012-05-19)
In this paper, novel liver-targeting nanoparticles (NPs), lactosyl-norcantharidin (Lac-NCTD)-associated N-trimethyl chitosan (TMC) NPs (Lac-NCTD-TMC-NPs), were prepared using ionic cross-linkage. The physical properties, particle size, and encapsulation efficiency of the nanoparticles were then investigated. The continuous line of heterogeneous human epithelial
Mark Tarleton et al.
European journal of medicinal chemistry, 54, 573-581 (2012-07-17)
Cantharidin (1) and norcantharidin (2) display high levels of anticancer activity against a broad range of tumour cell lines. Synthetic manipulation of norcantharidin yields (3S,3aR,4S,7R,7aS)-3-hydroxyhexahydro-4,7-epoxyisobenzofuran-1(3H)-one (3), which also displays a high level of anticancer activity against tumour cells but interestingly
Yong Li et al.
Frontiers in pharmacology, 11, 187-187 (2020-03-21)
Drug repositioning, development of new uses for marketed drugs, is an effective way to discover new antitumor compounds. In this study, we used a new method, filtering compounds via molecular docking to find key targets combination. The data of gene
Yong-yan Bei et al.
International journal of nanomedicine, 7, 1819-1827 (2012-05-24)
In this paper, two novel liver-targeting nanoparticles, norcantharidin-loaded chitosan nanoparticles (NCTD-CS-NPs) and norcantharidin-associated galactosylated chitosan nanoparticles (NCTD-GC-NPs), were prepared using ionic cross-linkage. The physical properties, particle size, encapsulation efficiency, and drug release characteristics of the nanoparticles were investigated in vitro.
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