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N6514

Sigma-Aldrich

Neuraminidase from Vibrio cholerae

Type II, buffered aqueous solution, 8-24 units/mg protein (Lowry, using NAN-lactose)

Sinonimo/i:

Acyl-neuraminyl Hydrolase, Receptor-destroying enzyme, Sialidase

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About This Item

Numero CAS:
9001-67-6
Classificazione EC (Enzyme Commission):
3.2.1.18 (BRENDA, IUBMB)
Numero CE:
232-624-6
Numero MDL:
MFCD00131711
Codice UNSPSC:
12352204
NACRES:
NA.54

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Origine biologica

Vibrio cholerae

Livello qualitativo

200

Tipo

Type II

Stato

buffered aqueous solution

Attività specifica

8-24 units/mg protein (Lowry, using NAN-lactose)

Attività estranea

Protease and NAN-aldolase, present

Temperatura di conservazione

2-8°C

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Categorie correlate

Descrizione generale

Calorimetry studies show that the two lectin-like domains flanking the central catalytic domain of Neuraminidase serve as the recognition and binding sites for sialic acid-containing substrates. [1]
Neuraminidase enzymes are hydrolase enzymes that promote influenza virus release from infected cells and facilitate virus spread.

Applicazioni

Neuraminidase from Vibrio cholera has been used in a study to describe a five-step purification method. [2] It has also been used in a study to investigate modification of leukemia L1210 tumor cells. [3]
Neurminidase is used as a cell-surface probe for glycoconjugate distribution and in substrate specificity studies.

Qualità

Preservative free.

Definizione di unità

One unit will liberate 1.0 μmole of N-acetylneuraminic acid per min at pH 5.0 at 37 °C using NAN-lactose or bovine submaxillary mucin, unless otherwise specified. Prices based on units using NAN-lactose as substrate.

Stato fisico

Solution in 50 mM sodium acetate, pH 5.5, containing 0.15 M sodium chloride and 4 mM calcium chloride, 0.2 μm filtered..

Nota sulla preparazione

A further purification by affinity chromatography of our Type III.

Pittogrammi

Health hazard
GHS08

Avvertenze

Danger

Indicazioni di pericolo

H334

Consigli di prudenza

P261 - P284 - P501

Classi di pericolo

Resp. Sens. 1

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
0000345920
0000345920
0000288201
0000221082
0000221082

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Ibrahim Moustafa et al.
The Journal of biological chemistry, 279(39), 40819-40826 (2004-07-01)
Vibrio cholerae neuraminidase (VCNA) plays a significant role in the pathogenesis of cholera by removing sialic acid from higher order gangliosides to unmask GM1, the receptor for cholera toxin. We previously showed that the structure of VCNA is composed of
S Crennell et al.
Structure (London, England : 1993), 2(6), 535-544 (1994-06-15)
Vibrio cholerae neuraminidase is part of a mucinase complex which may function in pathogenesis by degrading the mucin layer of the gastrointestinal tract. The neuraminidase, which has been the target of extensive inhibitor studies, plays a subtle role in the
Nicolas Burin des Roziers et al.
Transfusion, 55(6 Pt 2), 1563-1571 (2015-01-06)
Pneumococcal hemolytic uremic syndrome (P-HUS) is a rare but severe complication of invasive pneumococcal disease (IPD) in young children. Consensual biologic diagnosis criteria are currently lacking. A prospective study was conducted on 10 children with culture-confirmed IPD. Five presented with
Purification and Properties of Neuraminidase from Vibrio cholera
Ada, G., et al.
Microbiology, 24, 409-421 (1961)
Hirokazu Kai et al.
Bioorganic & medicinal chemistry, 20(8), 2739-2746 (2012-03-14)
A selective and potent inhibitor of neuraminidases, a hydrolase that is responsible for processing sialylated glycoconjugates, is a promising drug candidate for various infective diseases. The current study demonstrates that the use of an aglycone-focused library of 2-difluoromethylphenyl α-sialosides is
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Articoli

Sialic Acid

Understand sialic acid structure, function, signaling, and modifications. Easily find products for sialic acid research.

Protocolli

Enzymatic Assay of Neuraminidase

Enzymatic Assay of Neuraminidase applies to products that have a specification for neuraminidase content by enzymatic determination.

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