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M5793

Sigma-Aldrich

3-Morpholinosydnonimine hydrochloride

(consistent with structure, NMR)

Sinonimo/i:

3-(4-Morpholinyl)sydnone imine hydrochloride, Linsidomine hydrochloride, SIN-1 hydrochloride

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25 MG
CHF 391.00
100 MG
CHF 676.00

CHF 391.00

Spedizione prevista il29 maggio 2025

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25 MG
CHF 391.00
100 MG
CHF 676.00

About This Item

Formula empirica (notazione di Hill):
C6H10N4O2 · HCl
Numero CAS:
16142-27-1
Peso molecolare:
206.63
Numero MDL:
MFCD00214332
Codice UNSPSC:
12352200
ID PubChem:
24897048
NACRES:
NA.77

CHF 391.00

Spedizione prevista il29 maggio 2025

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Livello qualitativo

200

Temperatura di conservazione

−20°C

Stringa SMILE

Cl[H].[NH-]c1c[n+](no1)N2CCOCC2

InChI

1S/C6H10N4O2.ClH/c7-6-5-10(8-12-6)9-1-3-11-4-2-9;/h5,7H,1-4H2;1H
NCGICGYLBXGBGN-UHFFFAOYSA-N

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Categorie correlate

Applicazioni

3-Morpholinosydnonimine hydrochloride has been used:
  • as a peroxynitrite donor standard to study the accumulation of peroxynitrite in Arabidopsis thaliana[1]
  • to study its effects on nitrosative stress in human brain vascular pericytes and human embryonic kidney cells[2]
  • as a ROS to study its effects on mouse embryonic fibroblasts[3]

Azioni biochim/fisiol

3-Morpholinosydnonimine participates in the inhibition of cysteine proteases.[4]
Liberates nitric oxide (NO) spontaneously when in solution, activating guanylyl cyclase and causing an increase in cyclic-GMP. This product is a vasodilator and inhibits platelet aggregation. Using molecular oxygen, it generates both superoxide anion and nitric oxide that spontaneously form peroxynitrite.
Liberates nitric oxide (NO) spontaneously when in solution, activating guanylyl cyclase and causing an increase in cyclic-GMP; vasodilator.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
0000404431
0000404431
0000389762
0000303700
0000303700

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S-Nitroso-N-acetyl-DL-penicillamine ≥97%, powder

Sigma-Aldrich

N3398

S-Nitroso-N-acetyl-DL-penicillamine

(−)-Menthone analytical standard

Supelco

63677

(−)-Menthone

Sunset Yellow FCF Dye content 90 %

Sigma-Aldrich

465224

Sunset Yellow FCF

Diethylamine NONOate diethylammonium salt ≥98%

Sigma-Aldrich

D5431

Diethylamine NONOate diethylammonium salt

Superoxide Dismutase bovine recombinant, expressed in E. coli, lyophilized powder, ≥2500 units/mg protein, ≥90% (SDS-PAGE)

Sigma-Aldrich

S9697

Superoxide Dismutase bovine

Diethyl maleate 97%

Sigma-Aldrich

D97703

Diethyl maleate

Kittipot Sirichaiwetchakoon et al.
BioMed research international, 2020, 4183643-4183643 (2020-10-09)
Tea is one of the most popular beverages in the world. Camellia sinensis tea (CST) or green tea is widely regarded as a potent antioxidant. In Thailand, Pluchea indica (L.) Less. tea (PIT) has been commercially available as a health-promoting
P Ascenzi et al.
Current protein & peptide science, 2(2), 137-153 (2002-10-09)
Cysteine proteases represent a broad class of proteolytic enzymes widely distributed among living organisms. Although well known as typical lysosomal enzymes, cysteine proteases are actually recognized as multi-function enzymes, being involved in antigen processing and presentation, in membrane-bound protein cleavage
Keren Zohar et al.
Biomedicines, 9(9) (2021-09-29)
A hallmark of the aging brain is the robust inflammation mediated by microglial activation. Pathophysiology of common neurodegenerative diseases involves oxidative stress and neuroinflammation. Chronic treatment of aging rats by ladostigil, a compound with antioxidant and anti-inflammatory function, prevented microglial
Frank Gaupels et al.
Nitric oxide : biology and chemistry, 25(2), 222-228 (2011-02-08)
Nitric oxide (NO) is synthesized in plants in response to stress, and its role in signaling is well-documented. In contrast, very little is known about the physiological role of its derivate peroxynitrite (ONOO(-)), which forms when NO reacts with O(2)(-)
Tangying Lu et al.
The Journal of clinical investigation, 121(10), 4015-4029 (2011-09-14)
Cancer immunotherapeutic approaches induce tumor-specific immune responses, in particular CTL responses, in many patients treated. However, such approaches are clinically beneficial to only a few patients. We set out to investigate one possible explanation for the failure of CTLs to
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Articoli

DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research

DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research

Sensor Dyes

Nitric oxide (NO) as a signal transporter in neurons, endothelial cells and in the immune system.

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