The product is advised to be dissolved in anoxic water. The use of distilled water is not recommended, as it can absorb more oxygen from the atmosphere.
T4425
(6R)-5,6,7,8-Tetrahydrobiopterin dihydrochloride
≥98% (HPLC), powder
Sinonimo/i:
(6R)-BH4
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5 MG
CHF 114.00
25 MG
CHF 290.00
100 MG
CHF 1’260.00
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Cambia visualizzazione
5 MG
CHF 114.00
25 MG
CHF 290.00
100 MG
CHF 1’260.00
About This Item
Formula empirica (notazione di Hill):
C9H15N5O3 · 2HCl
Numero CAS:
Peso molecolare:
314.17
Numero MDL:
Codice UNSPSC:
12352200
ID PubChem:
NACRES:
NA.77
Prodotti consigliati
Nome del prodotto
(6R)-5,6,7,8-Tetrahydrobiopterin dihydrochloride,
Livello qualitativo
Solubilità
water, oxygen free: soluble 19.60-20.40 mg/mL, clear to slightly hazy, colorless to faintly yellow
Temperatura di conservazione
−20°C
Stringa SMILE
Cl.Cl.C[C@H](O)[C@H](O)[C@H]1CNC2=C(N1)C(=O)NC(N)=N2
InChI
1S/C9H15N5O3.2ClH/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7;;/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17);2*1H/t3-,4+,6-;;/m0../s1
RKSUYBCOVNCALL-NTVURLEBSA-N
Informazioni sul gene
human ... PAH(5053)
Descrizione generale
Tetrahydrobiopterin is a natural cofactor for phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, nitric oxide synthase and alkylglycerol monooxygenase.[1]
Applicazioni
(6R)-BH4 has been used as a buffer component for assaying tyrosine hydroxylase enzyme activity in mouse brain tissues. (6R)-BH4 has also been identified as an activator compound from a LOPAC library screen using a fluorogenic α-glucosidase assay.
Azioni biochim/fisiol
Caratteristiche e vantaggi
This compound is featured on the Dopamine, Norepinephrine and Epinephrine Synthesis and Nitric Oxide Synthases pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Nota sulla preparazione
(6R)-5,6,7,8-Tetrahydrobiopterin dihydrochloride ((6R)-BH4 ) is soluble in oxygen free water at 19.60 - 20.40 mg/ml and yields a clear to slightly hazy, colorless to faint yellow solution.
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Is the product T4425 (CAS 69056-38-8) soluble in distilled water?
1 answer-
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How should a solution of (6R)-5,6,7,8-tetrahydrobiopterin (hydrochloride) be stored? How long is it good for?
1 answer-
Tetrahydrobiopterin reacts with oxygen, particularly in neutral and alkaline solutions. The product should be reconstituted in oxygen-free water. Tetrahydrobiopterin solutions become yellow but are stable for several weeks at -20°C when prepared at 20-40 mg/mL in 0.1 N HCl.
Please review the product data sheet for more information on this product:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/277/129/t4425pis.pdfHelpful?
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