L9908

LY-294,002 hydrochloride

from microbial (Staphylococcus roseus), ≥98% (HPLC), solid, PI3K inhibitor

• Sinonimo/i: 2-(4-Morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride
• Formula empirica (notazione di Hill): C₁₉H₁₇NO₃ · HCl
• Numero CAS: 934389-88-5
• Peso molecolare: 343.80
• Numero MDL: MFCD00270881
• Codice UNSPSC: 12352207
• ID PubChem: 24278828
• NACRES: NA.77

Proprietà

• product name: LY-294,002 hydrochloride, solid, ≥98% (HPLC)
• Origine biologica: microbial (Staphylococcus roseus)
• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Forma fisica: solid
• Colore: white to off-white
• Solubilità: DMSO: >5 mg/mL; H₂O: insoluble
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: O=C1C=C(Oc2c1cccc2-c3ccccc3)N4CCOCC4
• InChI: 1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2; CZQHHVNHHHRRDU-UHFFFAOYSA-N

Descrizione

Descrizione generale

LY-294,002 hydrochloride is a derivative of the flavonoid, quercetin and elicits higher inhibition on the enzyme phosphoinositide 3-kinase (PI3K). LY-294,002 inhibits nuclear factor kappa B signaling in macrophages. It elevates expression of autophagosomal protein LC3 and promotes apoptosis in gastric and nasopharyngeal cancer cells. LY-294,002 modulates action potential repolarization and improves myocyte contractility.

Applicazioni

LY-294,002 hydrochloride has been used in the inhibition of:

• phosphoinositide 3-kinase (PI3K) in human lung cancer cell line
• autophagy in mesenchymal stem cells (MSCs).
• serine/threonine-specific protein kinase (AKT) signaling in fibroblasts and cardiac cells.

Azioni biochim/fisiol

Specific cell permeable phosphatidylinositol 3-kinase inhibitor.

Caratteristiche e vantaggi

This compound is a featured product for Cyclic Nucleotide and Kinase Phosphatase Biology research. Discover more featured Cyclic Nucleotide and Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the G Proteins (Heterotrimeric) and Phosphoinositide Kinases pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)