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Unless otherwise stated, this product is intended for research use only. It is not suitable for any other purpose, which includes, but is not limited to, unauthorized commercial use, in vitro diagnostic use, or therapeutic use in humans or animals.
M2272
Melittin from honey bee venom
≥85% (HPLC)
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| Voi/SKU | Disponibilità | Prezzo |
|---|---|---|
1 mg | Per conoscere la disponibilità, visualizza il carrello | CHF 189.00 |
5 mg | Per conoscere la disponibilità, visualizza il carrello | CHF 633.00 |
25 mg | Per conoscere la disponibilità, visualizza il carrello | CHF 1050.00 |
Informazioni su questo articolo
Formula empirica (notazione di Hill):
C131H229N39O31
Numero CAS:
Peso molecolare:
2846.46
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Servizio Tecnico
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Permettici di aiutartibiological source
animal (Apis mellifera)
Quality Segment
assay
≥85% (HPLC)
form
lyophilized powder
mol wt
~_2.8 kDa
solubility
water: 5.00-5.20 mg/mL, clear, colorless to faintly yellow
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
foreign activity
Phospholipase A2 ≤0.5%
mode of action
cell membrane | interferes
storage temp.
−20°C
SMILES string
CC[C@H](C)[C@H](NC(=O)CN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O
InChI
1S/C131H229N39O31/c1-23-71(16)102(163-97(176)60-135)122(194)146-62-98(177)148-74(19)109(181)164-100(69(12)13)124(196)160-88(55-65(4)5)116(188)155-84(41-30-33-51-134)115(187)165-101(70(14)15)125(197)161-90(57-67(8)9)118(190)168-106(77(22)173)128(200)169-105(76(21)172)123(195)147-63-99(178)150-92(58-68(10)11)129(201)170-54-36-44-94(170)121(193)149-75(20)108(180)158-89(56-66(6)7)117(189)166-104(73(18)25-3)127(199)162-93(64-171)120(192)159-91(59-78-61-145-80-38-27-26-37-79(78)80)119(191)167-103(72(17)24-2)126(198)157-83(40-29-32-50-133)111(183)154-85(42-34-52-143-130(139)140)112(184)152-82(39-28-31-49-132)110(182)153-86(43-35-53-144-131(141)142)113(185)156-87(46-48-96(137)175)114(186)151-81(107(138)179)45-47-95(136)174/h26-27,37-38,61,65-77,81-94,100-106,145,171-173H,23-25,28-36,39-60,62-64,132-135H2,1-22H3,(H2,136,174)(H2,137,175)(H2,138,179)(H,146,194)(H,147,195)(H,148,177)(H,149,193)(H,150,178)(H,151,186)(H,152,184)(H,153,182)(H,154,183)(H,155,188)(H,156,185)(H,157,198)(H,158,180)(H,159,192)(H,160,196)(H,161,197)(H,162,199)(H,163,176)(H,164,181)(H,165,187)(H,166,189)(H,167,191)(H,168,190)(H,169,200)(H4,139,140,143)(H4,141,142,144)/t71-,72-,73-,74-,75-,76+,77+,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,100-,101-,102-,103-,104-,105-,106-/m0/s1
InChI key
VDXZNPDIRNWWCW-JFTDCZMZSA-N
General description
Chemical structure: peptide
Melittin is hydrophobic in nature except for a region with Lys-Arg-Lys-Arg sequence near C-terminal end. This structural characteristic makes melittin a highly surface-active and a powerful, direct haemolytic agent.† The encoded protein containins 26 amino acids. Monomeric form of melittin has a molecular weight of 2,840 Daltons and tetrameric form has molecular weight of approximately 12,500 Daltons.
Application
Melittin from honey bee venom has been used:
- In 3-(4, 5-dimethyl thiazol-2-yl)-2,5diphenyl tetrazolium bromide (MTT) assay to determine its cytotoxicity effect on the growth of human cell lines.
- To study the anti-microbial activity of melittin on the growth of Borrelia burgdorferi in in vitro conditions.
- As a positive control in hemolysis assay and as a cytotoxic agent against HeLa cells.
Biochem/physiol Actions
Binds calmodulin in a Ca2+-dependent manner; inhibits Na+-K+-ATPase.
Melittin acts as an anti-coagulating protein by increasing the time of blood clotting in vitro. Melittin inhibits the activity of S100 calcium-binding protein B (S100B) and plays a vital role in Epilepsy treatment.
Other Notes
The principle hemolytic component of honeybee venom.
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Questo articolo | |||
|---|---|---|---|
| description ≥85% (HPLC) | description ≥65% (HPLC) | description salt-free, lyophilized powder, 600-2400 units/mg protein | description lyophilized powder, ≥300 units/g solid |
| assay ≥85% (HPLC) | assay - | assay - | assay - |
| biological source animal (Apis mellifera) | biological source - | biological source - | biological source - |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| form lyophilized powder | form lyophilized powder | form salt-free, lyophilized powder | form lyophilized powder |
| mol wt ~_2.8 kDa | mol wt ~_2.8 kDa | mol wt 14.5 kDa | mol wt - |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
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Parola di avvertenza
Danger
Codici di pericolo
Avvertenze di sicurezza
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Oral
Classe di stoccaggio
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
Che succede?
WGK 3
Punto di infiammabilità (°F)
Not applicable
Punto di infiammabilità (°C)
Not applicable
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