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I9385

Sigma-Aldrich

Anti-Human IgM (μ-chain specific) antibody produced in rabbit

whole antiserum

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About This Item

Numero MDL:
Codice UNSPSC:
12352203
NACRES:
NA.46

Origine biologica

rabbit

Coniugato

unconjugated

Forma dell’anticorpo

whole antiserum

Tipo di anticorpo

secondary antibodies

Clone

polyclonal

contiene

15 mM sodium azide

tecniche

indirect ELISA: 1:20,000

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

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Descrizione generale

IgM is a pentameric immunoglobulin, with each monomer having a light and heavy chain. The two types of IgM comprise natural and adaptive.

Applicazioni

Anti-Human IgM (μ-chain specific) antibody produced in rabbit has been used in enzyme linked immunosorbent assay.

Azioni biochim/fisiol

IgM antibodies are present as pentamers in the serum and are produced in response to antigens.
IgM serves as prime antibody in providing defense. It activates complement C1q. It is regarded as a marker for identifying tumor-associated antigens. Hyper-IgM syndrome is implicated with high IgM levels accompanied by low IgA, IgG and IgE levels.

Nota sulla preparazione

treated to remove lipoproteins

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter


Certificati d'analisi (COA)

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Evaluation of a patient with hyper-IgM syndrome
Uygungil B, et al.
The Journal of Allergy and Clinical Immunology, 129(6), 1692-1692 (2012)
The human IgM pentamer is a mushroom-shaped molecule with a flexural bias
Czajkowsky DM and Shao Z
Proceedings of the National Academy of Sciences of the USA, 106(35), 14960-14965 (2009)
Natural and adaptive IgM antibodies in the recognition of tumor-associated antigens of breast cancer
Diaz-Zaragoza M, et al.
Oncology Reports, 34(3), 1106-1114 (2015)
Antibodies reacting with human immunoglobulin in sera from autoimmune thyroid disease patients as a risk factor for false positive results in IgA assessment
Haroun M and El-Masry MH
Central European Journal of Immunology, 33, 208-212 (2008)
E J Wiersma et al.
Journal of immunology (Baltimore, Md. : 1950), 160(12), 5979-5989 (1998-06-24)
Previous studies have discerned two forms of polymeric mouse IgM: moderately cytolytic (complement-activating) pentamer, which contains J chain, and highly cytolytic hexamer, which lacks J chain. To investigate the relationships among polymeric structure, J chain content, and cytolytic activity, we

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