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I2644

Sigma-Aldrich

IL-2 human

≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Sinonimo/i:

IL-2, Interleukin-2, Interleukin-2 human, T-cell growth factor, hIL-2

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10 μG
CHF 511.00
5 X 10 μG
CHF 1’460.00

CHF 511.00

Spedizione prevista il01 giugno 2025

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Cambia visualizzazione
10 μG
CHF 511.00
5 X 10 μG
CHF 1’460.00

About This Item

Numero MDL:
MFCD00165721
Codice UNSPSC:
12352202
NACRES:
NA.77

CHF 511.00

Spedizione prevista il01 giugno 2025

Richiedi un ordine bulk

Nome del prodotto

Interleukin-2 human, IL-2, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Origine biologica

human

Livello qualitativo

200

Ricombinante

expressed in E. coli

Stato

lyophilized powder

Potenza

≤700 EC50

Qualità

endotoxin tested

PM

15.5 kDa

Confezionamento

pkg of 5X10 μg
pkg of 10 μg

tecniche

cell culture | mammalian: suitable

Impurezze

≤1 EU/μg

N° accesso UniProt

P60568

Temperatura di conservazione

−20°C

Informazioni sul gene

human ... IL2(3558)

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Categorie correlate

Descrizione generale

Interleukin-2 (IL-2) is an α-helical cytokine belonging to T-helper cell type 1. It has a molecular weight of 15kDa. The IL2 gene is mapped to human chromosome 4q27.[1] IL-2 is originally called as T cell growth factor.[2]

Applicazioni

Interleukin-2 human has been used:
  • in the stimulation of natural killer cells[3]
  • to study its ability to stimulate lymphocyte growth and prevent apoptosis[4]
  • as an antigen in enzyme-linked immunosorbent assay (ELISA), to analyse the human autoantibody reactivities in health and in type 1 diabetes mellitus[5]

Azioni biochim/fisiol

Interleukin-2 (IL-2) is an immunomodulatory factor produced by certain subsets of T lymphocytes. This lympho­kine promotes long term growth of acti­vated T cells and related cell types. IL-2 plays a role in the activation and proliferation of NK cells, induces γ-inter­feron and B cell growth factor secretion, and modulates the expression of the IL-2 receptor.
Interleukin-2 (IL-2) is essential for proliferation of natural killer (NK) cells, lymphocytes and macrophages.[1] It plays a key role in the immune system functions such as NK cell-stimulated immune responses. IL-2 also mediates the essential functions of regulatory T cells. It is implicated in autoimmune disease.[6] IL-2 is associated with apoptosis and thus, possesses antitumor response.[7] It mediates CD41+ T-cells differentiation into T-helper cell 1 and 2 effector subsets, preventing T-helper 17 differentiation.[1]

Stato fisico

Lyophilized, 0.2 μm filtered, no additives.

Risultati analitici

The biological activity is measured by the dose-dependent stimulation of the proliferation of murine CTLL-2 cells.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
0000293944
SLCF9838
SLBR5404V
SLBR0355V
SLBN3955V

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Sigma-Aldrich

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IL-15 human Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture

Sigma-Aldrich

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Interleukin-15 human >97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Sigma-Aldrich

I8648

Interleukin-15 human

Stefania Braidotti et al.
Frontiers in bioscience (Landmark edition), 27(2), 39-39 (2022-03-01)
The T-cell engager antibody blinatumomab (BlincytoT⁢M) represents a promising rescue therapy for relapsed/refractory CD19+ acute lymphoblastic leukemia (B-ALL), although ~20-30% of patients still do not respond to treatment. Blinatumomab creates a tight synapsis between CD3+ T-lymphocytes and leukemic CD19+ B-cells
Interleukin 2, 37-37 (2012)
Natural killer cells in the synovial fluid of rheumatoid arthritis patients exhibit a CD56bright, CD94bright, CD158negative phenotype
Pridgeon C, et al.
Rheumatology (Basel), 42(7), 870-878 (2003)
Kuan-Hui Ethan Chen et al.
Translational oncology, 14(11), 101195-101195 (2021-08-11)
Previous work has shown systemic knockdown of the long form prolactin receptor (LFPRLR) in vivo markedly reduced metastasis in mouse models of breast cancer, but whether this translated to prolonged survival was unknown. Here we show that LFPRLR knockdown in
Loss of immune tolerance to IL-2 in type 1 diabetes
Perol L, et al.
Nature Communications, 7(2), 13027-13027 (2016)
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Articoli

Interleukin Family (IL)

Interleukins, released from leukocytes, include IL-1β playing crucial roles in inflammation, immune responses, and anti-tumor immunity.

Questions

1–7 of 7 Questions  

  1. How to calculate the number of Units in the vial?

    1 answer

    1. The EC50 has been determined by dose-dependent stimulation of the proliferation of murine CTLL-2 cells. The EC50 value can be used to determine activity. The EC50 value is listed on the lot specific Certificate of Analysis. Certificates of Analysis can accessed in the DOCUMENTATION section of the product detail page:

      https://www.sigmaaldrich.com/product/sigma/i2644#product-documentation

      The specific activity in Units/mg can be calculated by the following:
      Activity = 1 × 106 / ED50 (in ng/ml).

      Helpful?

  2. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

  3. How should I dissolve Product I2644, Interleukin-2 human - recombinant?

    1 answer

    1. Reconstitute the contents of the vial using 100 mM acetic acid to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers.

      Helpful?

  4. Where can I find information on the specific activity of Product I2644, Interleukin-2 human - recombinant?

    1 answer

    1. The EC50 has been determined by dose-dependent stimulation of the proliferation of murine CTLL-2 cells.  You can find the lot specific value for the EC50 of this product on the Certificate of Analysis.  Certificates of Analysis can be viewed on our website by entering the lot number on the product detail page (for I2644).

      Helpful?

  5. How can I convert the EC50 of interleukin from ng/mL to units/mL when using Product I2644, Interleukin-2 human - recombinant?

    1 answer

    1. The specific activity in Units/mg = 1 × 106 / ED50 (in ng/ml).

      Helpful?

  6. Is Product I2644, Interleukin-2 human - recombinant, endotoxin tested?

    1 answer

    1. Yes, the endotoxin levels are reported on the Certificate of Analysis.  Certificates of Analysis can be viewed on our website by entering the lot number on the product page (for I2644).

      Helpful?

  7. How should solutions of Product I2644, Interleukin-2 human - recombinant, be stored?

    1 answer

    1. Interleukin solutions can be stored at 2-8°C for up to 1 week. For extended storage, freeze at -20°C in working aliquots to avoid freezing and thawing.

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