It is recommended that I7908 be reconstituted in 50mm Phosphate buffer, pH 7 containing 0.1 % BSA or HSA. Please see the link below the access the product datasheet for additional information:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/427/488/i7908dat.pdf
I7908
IL-2 human
≥98% (SDS-PAGE and HPLC), recombinant, expressed in Pichia pastoris, lyophiilized powder, suitable for cell culture
Sinonimo/i:
IL-2, Interleukin-2, T-cell growth factor
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10000 UNITS
CHF 507.00
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CHF 507.00
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Prodotti consigliati
Nome del prodotto
Interleukin-2 human, recombinant, expressed in Pichia pastoris, suitable for cell culture
Origine biologica
human
Livello qualitativo
Ricombinante
expressed in Pichia pastoris
Saggio
≥98% (SDS-PAGE and HPLC)
Stato
lyophilized powder
PM
predicted mol wt ~15 kDa
Confezionamento
pkg of 10KU
tecniche
cell culture | mammalian: suitable
Impurezze
endotoxin, tested
N° accesso UniProt
Condizioni di spedizione
dry ice
Temperatura di conservazione
−20°C
Informazioni sul gene
human ... IL2(3558)
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Applicazioni
Interleukin-2 human has been used to assess changes in tumor necrosis factor receptor 1 (TNFR1). It has also been used in TNFR2 expression on Tregs.[1]
Azioni biochim/fisiol
Interleukin 2 (IL2) is a pro-inflammatory cytokine.[2] It consists of three subunits, in which the β subunit is important for receptor mediated signaling.[3] IL2 enhances the development of T regulatory cells[4] and plays a crucial role in antitumor immunity.[2]
Interleukin-2 (IL-2) is an immunomodulatory factor produced by certain subsets of T lymphocytes. This lymphokine promotes long term growth of activated T cells and related cell types. IL-2 plays a role in the activation and proliferation of NK cells, induces γ-interferon and B cell growth factor secretion, and modulates the expression of the IL-2 receptor.
Stato fisico
Lyophilized from a 0.2 μm filtered solution in 50 mM sodium phosphate buffer, pH 7.0, containing 0.1% human serum albumin per 0.1 mL of cytokine.
Risultati analitici
The biological activity is tested in a cell proliferation assay using an IL-2 dependent murine cytotoxic T cell line, CTLL-2.
Codice della classe di stoccaggio
13 - Non Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
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Tenemos IL-2 expresado en Pichia Pastoris desde hace un tiempo con esta referencia (I7908) sin reconstituir. Hemos perdido el data sheet y no sabemos en qué solución debemos reconstituirlo. Contacte conmigo para resolver nuestra duda.
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