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I0161

Sigma-Aldrich

IWR-1

≥98% (HPLC), powder, Tankyrase1/2 inhibitor

Sinonimo/i:

4-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-N-8-quinolinyl-Benzamide, IWR1

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CHF 148.00
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CHF 559.00

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CHF 148.00
25 MG
CHF 559.00

About This Item

Formula empirica (notazione di Hill):
C25H19N3O3
Numero CAS:
1127442-82-3
Peso molecolare:
409.44
Codice UNSPSC:
12352200
ID PubChem:
329815302
NACRES:
NA.77

CHF 148.00

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Nome del prodotto

IWR-1, ≥98% (HPLC)

Livello qualitativo

100

Saggio

≥98% (HPLC)

Colore

white to beige

Solubilità

DMSO: 5 mg/mL, clear

Temperatura di conservazione

room temp

Stringa SMILE

O=C(Nc1cccc2cccnc12)c3ccc(cc3)N4C(=O)[C@@H]5[C@H]6C[C@H](C=C6)[C@@H]5C4=O

InChI

1S/C25H19N3O3/c29-23(27-19-5-1-3-14-4-2-12-26-22(14)19)15-8-10-18(11-9-15)28-24(30)20-16-6-7-17(13-16)21(20)25(28)31/h1-12,16-17,20-21H,13H2,(H,27,29)/t16-,17+,20-,21+
ZGSXEXBYLJIOGF-ALFLXDJESA-N

Applicazioni

IWR-1 has been used as an antagonist for Wingless/Integrated (WNT) signaling pathway in human embryonic stem cells (hESCs),[1] mice lewis lung carcinoma (LLC)[2] and Sepia embryos.[3]

Azioni biochim/fisiol

IWR-1 is a tankyrase inhibitor and is cytotoxic for cancer stem-like cells. It inhibits the in vivo progression of osteosarcoma.[4] IWR-1 interacts with RNA polymerase II and is crucial for the formation of preinitiation complex.[5]
The Wnt/b-catenin (‘canonical′) pathway maintains transcriptional programs that enable stem cells to remain multipotent.
The Wnt/b-catenin (‘canonical′) pathway maintains transcriptional programs that enable stem cells to remain multipotent. Hyperactivation of the Wnt/b-catenin pathway leads to disease stage. IWR-3 act as inhibitors of Wnt response. It appear that IWR compounds induce stabilization of Axin proteins via a direct interaction, which is a part of the b-catenin destruction complex (consists of Apc, Axin, Ck1 and Gsk3b).

Caratteristiche e vantaggi

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
0000392843
0000392842
0000339126
0000329330
0000329332

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IWP-2 InSolution, ≥99%, 10 mM in DMSO, A cell-permeable benzothiazolyl-acetamide compound, Wnt Antagonist II

Sigma-Aldrich

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Sigma-Aldrich

5.00496

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Sigma-Aldrich

5.04907

Tankyrase 1/2 Inhibitor VI, G007-LK

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Sigma-Aldrich

C0742

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Sigma-Aldrich

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Acido retinoico

Hirokazu Narita et al.
Scientific reports, 7(1), 13708-13708 (2017-10-24)
One of the major challenges in cell-based cardiac regenerative medicine is the in vitro construction of three-dimensional (3D) tissues consisting of induced pluripotent stem cell-derived cardiomyocyte (iPSC-CM) and a blood vascular network supplying nutrients and oxygen throughout the tissue after
Iwr1 protein is important for preinitiation complex formation by all three nuclear RNA polymerases in Saccharomyces cerevisiae
Esberg A, et al.
PLoS ONE, 6(6), e20829-e20829 (2011)
Efficient differentiation of TBX18+/WT1+ epicardial-like cells from human pluripotent stem cells using small molecular compounds
Zhao J, et al.
Stem Cells and Development, 26(7), 528-540 (2017)
A serine in exon 11 determines the full transcriptional activity of TCF-4 in lung carcinoma cells
Yang B, et al.
Biochemical and biophysical research communications, 508(3), 675-681 (2019)
Fei Gao et al.
Cancer letters, 402, 177-189 (2017-06-13)
Akt1 is essential for the oncogenic transformation and tumor growth in various cancers. However, the precise role of Akt1 in advanced cancers is conflicting. Using a neuroendocrine TRansgenic Adenocarcinoma of the Mouse Prostate (TRAMP) model, we first show that the
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