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SML0443

Sigma-Aldrich

SU-5402

≥98% (HPLC), powder, FGFR inhibitor

Sinonimo/i:

3-[4-Methyl-2-(2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1H-pyrrol-3-yl]-propionic acid, PF-02969207, PNU-0290908

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About This Item

Formula empirica (notazione di Hill):
C17H16N2O3
Numero CAS:
215543-92-3
Peso molecolare:
296.32
Numero MDL:
MFCD08235144
Codice UNSPSC:
51111800
ID PubChem:
329824725
NACRES:
NA.77

product name

SU-5402, ≥98% (HPLC)

Saggio

≥98% (HPLC)

Forma fisica

powder

Colore

light yellow to dark orange

Solubilità

DMSO: 10 mg/mL (clear solution)

Temperatura di conservazione

−20°C

Stringa SMILE

Cc1c[nH]c(\C=C2/C(=O)Nc3ccccc23)c1CCC(O)=O

InChI

1S/C17H16N2O3/c1-10-9-18-15(11(10)6-7-16(20)21)8-13-12-4-2-3-5-14(12)19-17(13)22/h2-5,8-9,18H,6-7H2,1H3,(H,19,22)(H,20,21)/b13-8-
JNDVEAXZWJIOKB-JYRVWZFOSA-N

Applicazioni

SU5402 has been used as a fibroblast growth factor receptor inhibitor:
  • in cell signalling experiments to stimulate cells for MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay
  • to study its effect on the expression of osteogenic markers and expression of osteoprotegerin and RANKL (runt-related transcription factor(RUNX)-2
  • to prepare a stock solution with DMSO (Dimethyl superoxide) for cell culture medium and also to co-treat embryos
  • to study its effect on osteogenic markers.

Azioni biochim/fisiol

SU-5402 has inhibitory effect on the action of tyrosine kinases. It competitively binds to the ATP-binding site on the fibroblast growth factor receptor (FGFR).
SU-5402 is a FGFR antagonist and angiogenesis inhibitor.

Caratteristiche e vantaggi

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Altre note

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Fibroblast growth factor 21 plays an inhibitory role in vascular calcification in vitro through OPG/RANKL system
Cao F, et al.
Biochemical and Biophysical Research Communications, 491(3), 578-586 (2017)
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