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G8634

Sigma-Aldrich

Guanosine 5′-[γ-thio]triphosphate tetralithium salt

≥90% (contains < 10% GDP, HPLC), powder

Sinonimo/i:

GTPγS tetralithium salt, GTP-γ-S-Li4, Guanosine 5′-O-(3-thiotriphosphate) tetralithium salt

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1 MG
CHF 82.20
5 MG
CHF 356.00
10 MG
CHF 616.00
25 MG
CHF 925.00

CHF 82.20

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Cambia visualizzazione
1 MG
CHF 82.20
5 MG
CHF 356.00
10 MG
CHF 616.00
25 MG
CHF 925.00

About This Item

Formula empirica (notazione di Hill):
C10H12Li4N5O13P3S
Numero CAS:
94825-44-2
Peso molecolare:
562.98
Beilstein:
8182249
Numero CE:
305-606-1
Numero MDL:
MFCD00135151
Codice UNSPSC:
41106305
ID PubChem:
24895344
NACRES:
NA.77

CHF 82.20

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Livello qualitativo

200

Saggio

≥90% (contains < 10% GDP, HPLC)

Stato

powder

Colore

white to off-white

Solubilità

H2O: ≥75 mg/mL (Solutions are very unstable; prepare immediately prior to use.)

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

Stringa SMILE

[Li+].[Li+].[Li+].[Li+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=S)[C@@H](O)[C@H]3O)C(=O)N1

InChI

1S/C10H16N5O13P3S.4Li/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(26-9)1-25-29(19,20)27-30(21,22)28-31(23,24)32;;;;/h2-3,5-6,9,16-17H,1H2,(H,19,20)(H,21,22)(H2,23,24,32)(H3,11,13,14,18);;;;/q;4*+1/p-4/t3-,5-,6-,9-;;;;/m1..../s1
AMQXJFWJOAWCPV-ZVQJTLEUSA-J

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Applicazioni

Guanosine 5′-[γ-thio]triphosphate tetralithium salt has been used:
  • as a component of lysis buffer[1]
  • in oocyte and mammalian cell patch-clamp experiments to keep the G proteins in a constantly active state[2]
  • to couple with G- protein α, to study its effect on kinase activity[3]

Azioni biochim/fisiol

GTP-γ-S is a non-hydrolyzable GTP analog, known for its role as a G-protein activator. It has recently been shown to protect proteins from proteolytic degradation, stimulate GLUT4 translocation in a tyrosine kinase-dependent manner, stimulate phospholipases and induce actin polymerization in vitro.

Caratteristiche e vantaggi

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
0000387141
0000376017
0000376016
0000376018
0000340487

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