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C8661

Sigma-Aldrich

Cobalt(II) chloride hexahydrate

BioReagent, suitable for cell culture, suitable for insect cell culture

Sinonimo/i:

Cobaltous chloride hexahydrate

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25 G
CHF 53.60
100 G
CHF 180.00

CHF 53.60

Spedizione prevista il21 marzo 2025

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Cambia visualizzazione
25 G
CHF 53.60
100 G
CHF 180.00

About This Item

Formula condensata:
CoCl2 · 6H2O
Numero CAS:
7791-13-1
Peso molecolare:
237.93
Numero CE:
231-589-4
Numero MDL:
MFCD00149652
Codice UNSPSC:
12352207
ID PubChem:
24893093
NACRES:
NA.71
Stato:
powder

CHF 53.60

Spedizione prevista il21 marzo 2025

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Tensione di vapore

40 mmHg ( 0 °C)

Livello qualitativo

300

Nome Commerciale

BioReagent

Stato

powder

tecniche

cell culture | insect: suitable
cell culture | mammalian: suitable

Stringa SMILE

O.O.O.O.O.O.Cl[Co]Cl

InChI

1S/2ClH.Co.6H2O/h2*1H;;6*1H2/q;;+2;;;;;;/p-2
GFHNAMRJFCEERV-UHFFFAOYSA-L

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Applicazioni

  • Synthesis, Characterization, and Biological Activities of Novel Vanadium(IV) and Cobalt(II) Complexes: Investigates the synthesis of novel cobalt(II) complexes and their potential biological applications, particularly emphasizing their bioactive properties in various cellular models (Damena T, Zeleke D, Desalegn T, et al. 2022. ACS Omega).

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Avvertenze

Danger

Classi di pericolo

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B Inhalation - Eye Dam. 1 - Muta. 2 - Repr. 1B - Resp. Sens. 1 - Skin Sens. 1

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificati d'analisi (COA)

Lot/Batch Number
0000357466
0000374149
0000370222
0000370224
0000368596

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The detailed mechanisms underlying oxidative stress that leads to neuroinflammation and neurodegeneration in retinal vascular conditions, including diabetic retinopathy, retinopathy of prematurity etc., remain largely unexplored mainly due to a lack of suitable disease models that can simulate the inherent
Baoan Hong et al.
International journal of biological sciences, 15(3), 587-597 (2019-02-13)
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Liver ischemia reperfusion injury (LIRI) is a common problem during surgical procedures of the liver. It causes severe inflammatory responses and cell death, eventually leading to serious liver damage. Agmatine (AGM) is an endogenous polyamine with analgesic, anti-inflammatory, and antiapoptotic
Yuan Zhang et al.
Clinica chimica acta; international journal of clinical chemistry, 489, 203-211 (2017-12-11)
Accumulated data indicate that placental hypoxia is implicated in the pathogenesis of preeclampsia (PE). Tight junction (TJ) is important structure that sustains normal placental barrier function, its dysregulation under hypoxia has been observed. This study was designed to explore hypoxia-induced
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Questions

1–3 of 3 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  3. Can C8661 be used in normoxia to induce hypoxia?

    1 answer

    1. CoCl2 is generally known to replace Fe2+ that binds to prolyl hydroxylase (PHD), which degrades hypoxia-inducible factor‑1α (HIF-1a) under normoxic conditions. This binding blocks the activity of PHD and subsequently upregulates the level of HIF-1a to simulate hypoxic conditions.

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