This product is not sterile. The solution may be filter-sterilized, however gravity or very low pressure is recommended, as strong positive or negative pressure during the filtration process may cause precipitation. Note that this product has not been tested for use in cell culture.
15862
Cobalt chloride 0.1 M solution
Sinonimo/i:
Cobalt(II)-chloride solution, Additive Screening Solution 24/Kit-No 78374
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Informazioni su questo articolo
Numero CAS:
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352302
MDL number:
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Servizio Tecnico
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Permettici di aiutartiQuality Segment
density
1.01 g/mL at 20 °C
storage temp.
2-8°C
SMILES string
Cl[Co]Cl
InChI
1S/2ClH.Co/h2*1H;/q;;+2/p-2
InChI key
GVPFVAHMJGGAJG-UHFFFAOYSA-L
Application
Cobalt chloride 0.1M solution has been used to simulate hypoxic exposure and HIF-1 (hypoxia-inducible factor 1) expression in prostate cancer cells. It has been used to induce hypoxia in human intestinal epithelial cells.
Biochem/physiol Actions
Cobalt chloride induces hypoxia condition in cells by upregulating hypoxia-inducible factor-1α (HIF-1α), erythropoietin and glycolytic enzymes. It is also responsible for mitochondrial DNA damage in rat neuronal PC12 cells. It is also responsible for the induction of apoptosis.
Cobalt chloride 0.1M solution is an additive screening solution of Additive Screening Kit. Additive Screen kit is designed to allow rapid and convenient evaluation of additives and their ability to influence the crystallization of the sample. The Additive Kit provides a tool for refining crystallization conditions.
Cobalt chloride 0.1M solution is an additive screening solution of Additive Screening Kit. Additive Screen kit is designed to allow rapid and convenient evaluation of additives and their ability to influence the crystallization of the sample. The Additive Kit provides a tool for refining crystallization conditions.
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| Quality Level 100 | Quality Level 200 | Quality Level 100 | Quality Level 200 |
| density 1.01 g/mL at 20 °C | density - | density - | density - |
| storage temp. 2-8°C | storage temp. - | storage temp. - | storage temp. - |
signalword
Danger
hcodes
Hazard Classifications
Aquatic Chronic 2 - Carc. 1B - Repr. 1B
Classe di stoccaggio
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
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Is this product sterile?
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How long can this be stored for at 2-8 degrees?
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This product is not assigned an expiration date or recommended retest date. Products with no expiration date or recommended retest date should be routinely inspected by customers to ensure they perform as expected. These products are also subject to a one year warranty from the date of shipment. For more information you may access the "Product Dating Information" document under "ADDITIONAL USEFUL DOCUMENTS ABOUT OUR PRODUCTS" at the bottom of the Quality Services page with this link: https://www.sigmaaldrich.com/life-science/quality-and-regulatory-management/quality-services
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