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C3411

Sigma-Aldrich

2′,7′-Bis(2-carboxyethyl)-5(6)-carboxyfluorescein

≥90% (HPLC)

Sinonimo/i:

BCECF

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About This Item

Formula empirica (notazione di Hill):
C27H20O11
Numero CAS:
85138-49-4
Peso molecolare:
520.44
Beilstein:
8375770
Numero MDL:
MFCD00036970
Codice UNSPSC:
12352200
ID PubChem:
24892612
NACRES:
NA.32

Livello qualitativo

100

Saggio

≥90% (HPLC)

Forma fisica

powder

Temperatura di conservazione

−20°C

Stringa SMILE

OC(=O)CCc1cc2c(OC3=CC(=O)C(CCC(O)=O)=CC3=C2c4cc(ccc4C(O)=O)C(O)=O)cc1O

InChI

1S/C27H20O11/c28-19-10-21-17(7-12(19)2-5-23(30)31)25(16-9-14(26(34)35)1-4-15(16)27(36)37)18-8-13(3-6-24(32)33)20(29)11-22(18)38-21/h1,4,7-11,28H,2-3,5-6H2,(H,30,31)(H,32,33)(H,34,35)(H,36,37)
DKROGDOAOXDINY-UHFFFAOYSA-N

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Applicazioni

2′,7′-Bis(2-carboxyethyl)-5(6)-carboxyfluorescein has been used in a fluorescence-based screening assay, to determine the pH.

Azioni biochim/fisiol

2′,7′-Bis(2-carboxyethyl)-5(6)-carboxyfluorescein (BCECF) is useful to study multidrug resistance-associated protein (MRP) transporter action within the cell. BCECF is known to interfere with drug efflux interactions.
Fluorescent indicator for measurement of cytoplasmic pH in lymphocytes.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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Alexander A Tokmakov et al.
Biochemical and biophysical research communications, 517(1), 140-145 (2019-07-20)
Mitogen-activated protein kinases (MAPKs) are involved in the regulation of various cellular processes, including cell survival and apoptosis. Here, we report that Xenopus p42 MAPK becomes phosphorylated in apoptotic eggs, however this modification does not activate the enzyme. Using phosphorylation
Adelaide S M Dennis et al.
Scientific reports, 8(1), 8795-8795 (2018-06-13)
Four hundred structurally diverse drug-like compounds comprising the Medicines for Malaria Venture's 'Pathogen Box' were screened for their effect on a range of physiological parameters in asexual blood-stage malaria (Plasmodium falciparum) parasites. Eleven of these compounds were found to perturb
High-throughput workflow for monitoring and mining bioprocess data: Application to infer E. coli physiological response to perturbations.
Heux S, et al.
Applied and Environmental Microbiology, AEM-05838 (2011)
Patrick Hofmann et al.
Cardiovascular research, 115(1), 230-242 (2018-08-15)
Long non-coding RNAs (lncRNAs) have been shown to regulate numerous processes in the human genome, but the function of these transcripts in vascular aging is largely unknown. We aim to characterize the expression of lncRNAs in endothelial aging and analyse
Chang-Yin Lee et al.
Oncology reports, 37(1), 399-407 (2016-11-15)
Panax notoginseng (P. notoginseng) and its components are used as traditional Chinese medicine for cardiovascular disease, although studies concerning the anti-metastatic properties of these compounds are limited. The goal of this study was to investigate the effects of notoginsenoside R1 (NGR1), an important
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