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C2743
Citocalasina B
Ready Made Solution, 10 mg/mL in DMSO
Sinonimo/i:
Phomin
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Cambia visualizzazione
200 μL
CHF 218.00
About This Item
Formula empirica (notazione di Hill):
C29H37NO5
Numero CAS:
Peso molecolare:
479.61
Beilstein:
1096207
Numero MDL:
Codice UNSPSC:
51102829
ID PubChem:
NACRES:
NA.85
Prodotti consigliati
Livello qualitativo
Stato
solution
Concentrazione
10 mg/mL in DMSO
Spettro attività antibiotica
fungi
Modalità d’azione
cell membrane | interferes
Temperatura di conservazione
−20°C
Stringa SMILE
C[C@@H]1CCC[C@@H](O)\C=C\C(=O)O[C@]23[C@@H](\C=C\C1)[C@H](O)C(=C)[C@@H](C)[C@H]2[C@H](Cc4ccccc4)NC3=O
InChI
1S/C29H37NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14-16,18-19,22-24,26-27,31,33H,3,7,9-10,13,17H2,1-2H3,(H,30,34)/b14-8+,16-15+/t18-,19-,22-,23+,24+,26+,27-,29-/m1/s1
GBOGMAARMMDZGR-TYHYBEHESA-N
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Applicazioni
Cytochalasin B from Drechslera dematioidea has been used:
- to block cytokinesis, to obtain binucleated cells[1]
- as a specific glucose transporter inhibitor[2]
- to inhibit glucose transport by class I and III GLUTs to determine the 50% inhibitory concentration (IC50) in HCMV-infected and mock-infected cells[3]
Azioni biochim/fisiol
Appartiene a un gruppo di metaboliti fungini che interferiscono con un′ampia varietà di movimenti cellulari. Utile strumento per la caratterizzazione di alcune delle proprietà di polimerizzazione dell′actina e negli studi sulla citochinesi. Sonda per i due sistemi di trasporto dell′esosio nei mioblasti L6 del ratto.
Cell permeable fungal toxin that disrupts contractile microfilaments by inhibiting actin polymerization. This, in turn, induces DNA fragmentation, inhibits cell division, and disrupts many cell processes. Inhibits glucose transport.
Cytochalasin B can prevent cytoplasmic division without affecting nuclear division.[7]
Altre note
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Avvertenze
Danger
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Acute Tox. 2 Inhalation - Acute Tox. 4 Oral
Codice della classe di stoccaggio
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
Classe di pericolosità dell'acqua (WGK)
WGK 2
Punto d’infiammabilità (°F)
185.0 °F - closed cup - Solvent
Punto d’infiammabilità (°C)
85 °C - closed cup - Solvent
Dispositivi di protezione individuale
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
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Certificati d'analisi (COA)
Lot/Batch Number
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What is the Department of Transportation shipping information for this product?
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Is Product C2743, Cytochalasin B, cell culture grade?
1 answer-
The product has been sterile filtered, but it has not been cell culture tested by Sigma.
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How does the storage temperature relate to shipping conditions?
1 answer-
The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.
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I have a solution of Product C2743, Cytochalasin B, in DMSO. Is the DMSO toxic to cultured cells?
1 answer-
At a low enough concentration, the DMSO should not hurt the cells. The final concentration of DMSO in the aqueous working medium typically should not exceed 0.1% because higher DMSO concentrations can adversely affect many cultured cells. Dilute the product in the appropriate aqueous medium to provide a physiologically acceptable final concentration.
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