This product is not assigned a firm expiration date, but lots are retested every 2 years while available to assure quality. In the original sealed container, this compound is quite stable. Exposure to light and moisture may accelerate degradation over time. A specific time frame related to the degradation rate has not been established.
C9754
Colchicina
≥95% (HPLC), powder, antimitotic agent
Sinonimo/i:
(S)-N-(5,6,7,9-tetraidro-1,2,3,10-tetrametossi-9-ossobenzo[a]eptalene-7-il)acetamide
Autenticati per visualizzare i prezzi organizzativi e contrattuali.
Scegli un formato
Cambia visualizzazione
| Voi/SKU | Disponibilità | Prezzo |
|---|---|---|
100 mg | Per conoscere la disponibilità, visualizza il carrello | CHF 31.80 |
500 mg | Per conoscere la disponibilità, visualizza il carrello | CHF 100.00 |
1 g | Per conoscere la disponibilità, visualizza il carrello | CHF 174.00 |
5 g | Per conoscere la disponibilità, visualizza il carrello | CHF 396.00 |
Informazioni su questo articolo
Formula empirica (notazione di Hill):
C22H25NO6
Numero CAS:
Peso molecolare:
399.44
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
200-598-5
MDL number:
Beilstein/REAXYS Number:
2228813
Assay:
≥95% (HPLC)
Form:
powder
Servizio Tecnico
Hai bisogno di aiuto? Il nostro team di scienziati qualificati è a tua disposizione.
Permettici di aiutartiNome del prodotto
Colchicina, ≥95% (HPLC), powder
Quality Segment
assay
≥95% (HPLC)
form
powder
color
white to yellow
mp
150-160 °C (dec.) (lit.)
solubility
ethanol: 50 mg/mL
SMILES string
COC1=CC=C2C(=CC1=O)[C@H](CCc3cc(OC)c(OC)c(OC)c23)NC(C)=O
InChI
1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1
InChI key
IAKHMKGGTNLKSZ-INIZCTEOSA-N
Gene Information
General description
Colchicine is a secondary metabolite, which has anti-inflammatory properties. It is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, Behçet disease, vasculitides and pericarditis. Colchicine inhibits cell division, intracellular vesicle motility, secretion of cytokines and chemokines. It is implicated in leukocyte diapedesis and lysosomal degranulation. Colchicine also blocks fibroblast proliferation and collagen transport to extracellular space.
Application
Colchicine has been used:
- in the in vitro sister-chromatid exchange (SCE) assay
- to study its in vitro antiviral, antibacterial, antifungal and cytotoxic activities
- in microtubule disruption
- to analyse its effects on Ca2+ transients from taxol-treated cells
Biochem/physiol Actions
Antimitotic agent that disrupts microtubules by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
Features and Benefits
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Preparation Note
This product in powdered format can be stored in room temperature. Colchicine powder will darken upon exposure to light. Colchicine solutions can be sterilized by autoclaving or filtration. Sterilized solutions are stable for at least six months if protected from light. No appreciable colchicine hydrolysis occurred in neutral and slightly alkaline (pH = 8.1) solutions after storage frozen for 2 months.
1 of 1
Questo articolo | |||
|---|---|---|---|
| description ≥95% (HPLC), powder | description suitable for plant cell culture, BioReagent, ≥95% (HPLC) | description phyproof® Reference Substance | description United States Pharmacopeia (USP) Reference Standard |
| form powder | form powder | form - | form - |
| assay ≥95% (HPLC) | assay ≥95% (HPLC) | assay ≥95.0% (HPLC) | assay - |
| Quality Level 200 | Quality Level 200 | Quality Level - | Quality Level - |
| solubility ethanol: 50 mg/mL | solubility - | solubility - | solubility - |
| color white to yellow | color - | color - | color - |
| mp 150-160 °C (dec.) (lit.) | mp 150-160 °C (dec.) (lit.) | mp 150-160 °C (dec.) (lit.) | mp 150-160 °C (dec.) (lit.) |
Still not finding the right product?
Explore all of our products under Colchicina
Parola di avvertenza
Danger
Codici di pericolo
Avvertenze di sicurezza
Hazard Classifications
Acute Tox. 2 Oral - Muta. 1B
Classe di stoccaggio
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
Che succede?
WGK 3
Punto di infiammabilità (°F)
Not applicable
Punto di infiammabilità (°C)
Not applicable
DPI (dispositivi di protezione individuale)
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Scegli una delle versioni più recenti:
Possiedi già questo prodotto?
I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
-
How long is this powder stable at room temperature approximately? After how many years is appreciable degradation to be expected?
1 answer-
Helpful?
-
-
How should this colchicine be dissolved to create a solution?
1 answer-
This material is soluble in ethanol at 50 mg/mL and water at 45 mg/mL. Stock solutions may be autoclaved or filter sterilized. The compound is light sensitive. Stock solutions should be stored protected from light in amber glass bottles and are stable for at least 6 months at 2 - 8°C.
Helpful?
-
-
What is the solubility of product C9754, Colchicine? Also, what is the solution stability of Colchicine?
1 answer-
The solubility of Colchicine in DMSO is 426 mg/ml at 25 °C. It can also be dissolved in absolute ethanol (50 mg/ml), producing a clear to slightly hazy, yellow to yellow-green solution. However, this may require heat.
Regarding solution stability, Colchicine powder darkens upon exposure to light. Sterilized solutions remain stable for at least six months if shielded from light. No significant hydrolysis of colchicine occurred in neutral and slightly alkaline solutions after two months of frozen storage.
Helpful?
-
-
How should Colchicine be stored as a powder and when dissolved? At which temperature?
1 answer-
This product in powdered format can be stored in room temperature. Colchicine powder will darken upon exposure to light. Colchicine solutions can be sterilized by autoclaving or filtration. Sterilized solutions are stable for at least six months if protected from light. No appreciable colchicine hydrolysis occurred in neutral and slightly alkaline (pH = 8.1) solutions after storage frozen for 2 months.
Helpful?
-