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C0400

Sigma-Aldrich

Carmustine

≥98% (TLC), oily liquid to amorphous solid, DNA alkylating agent

Sinonimo/i:

1,3-Bis(2-chloroethyl)-1-nitrosourea, BCNU

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25 MG
CHF 103.00
100 MG
CHF 314.00

CHF 103.00

Spedizione prevista il22 marzo 2025

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25 MG
CHF 103.00
100 MG
CHF 314.00

About This Item

Formula empirica (notazione di Hill):
C5H9Cl2N3O2
Numero CAS:
154-93-8
Peso molecolare:
214.05
Numero CE:
205-838-2
Numero MDL:
MFCD00057706
Codice UNSPSC:
12352200
ID PubChem:
24278289
NACRES:
NA.77

CHF 103.00

Spedizione prevista il22 marzo 2025

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Nome del prodotto

Carmustine, ≥98%

Livello qualitativo

200

Saggio

≥98%

Stato

(Oily liquid to amorphous solid)

Punto di fusione

30 °C (lit.)

Solubilità

ethanol: 19.60-20.40 mg/mL, clear, pale yellow to yellow

Ideatore

Bristol-Myers Squibb

Temperatura di conservazione

−20°C

Stringa SMILE

ClCCNC(=O)N(CCCl)N=O

InChI

1S/C5H9Cl2N3O2/c6-1-3-8-5(11)10(9-12)4-2-7/h1-4H2,(H,8,11)
DLGOEMSEDOSKAD-UHFFFAOYSA-N

Informazioni sul gene

human ... GSR(2936)

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Descrizione generale

Carmustine is a mustard gas related β-chloro-nitrosourea compound, which is used in chemotherapy. It inhibits DNA replication and DNA transcription.[1]

Applicazioni

Carmustine has been used to select transduced cells expressing MGMTP140K, a foamy virus vector.[2] It has also been used in fluorescence-activated cell sorting (FACS) assay, to test the response of cell lines to carmustine.[3]

Azioni biochim/fisiol

Carmustine is a DNA alkylating agent causing DNA interstrand crosslinks.[4] Effective against glioma and other solid tumors.

Caratteristiche e vantaggi

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pittogrammi

Skull and crossbonesHealth hazard
GHS06,GHS08

Avvertenze

Danger

Indicazioni di pericolo

H300,H350,H360

Consigli di prudenza

P201 - P301 + P310 + P330

Classi di pericolo

Acute Tox. 2 Oral - Carc. 1B - Repr. 1B

Codice della classe di stoccaggio

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificati d'analisi (COA)

Lot/Batch Number
0000415088
0000415088
0000224891
0000142953
0000139073

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Mapping the human kinome in response to DNA damage
Owusu M, et al.
Testing, 26(3), 555-563 (2019)
Foamy viral vector integration sites in SCID-repopulating cells after MGMTP140K-mediated in vivo selection
Olszko ME, et al
Gene Therapy, 22(7), 591-591 (2015)
Ching-Hsiang Fan et al.
Biomaterials, 34(8), 2142-2155 (2012-12-19)
Current chemotherapeutic agents do not only kill tumor cells but also induce systemic toxicity that significantly limits their dosage. Focused ultrasound (FUS) in the presence of microbubbles (MBs) is capable of transient and local opening of the blood-brain barrier (BBB)
John Blazeck et al.
Biotechnology journal, 5(7), 647-659 (2010-02-13)
The advent of high throughput genome-scale bioinformatics has led to an exponential increase in available cellular system data. Systems metabolic engineering attempts to use data-driven approaches--based on the data collected with high throughput technologies--to identify gene targets and optimize phenotypical
W Stahl et al.
Chemical research in toxicology, 5(1), 106-109 (1992-01-01)
S-[(2-Chloroethyl)carbamoyl]glutathione (SCCG), a compound formed during the decomposition of BCNU in the presence of GSH, induces DNA damage in a human lymphoblastoid cell line. This GSH conjugate was shown by direct fast atom bombardment mass spectrometric analysis to transfer an
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