239765
Cycloheximide
InSolution, 100 mg/mL in DMSO, Suitable for cell culture
Sinonimo/i:
InSolution Cycloheximide
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1 ML
CHF 103.00
CHF 103.00
Spedizione prevista il28 maggio 2025
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Cambia visualizzazione
1 ML
CHF 103.00
About This Item
Formula empirica (notazione di Hill):
C15H23NO4
Numero CAS:
Peso molecolare:
281.35
Numero MDL:
Codice UNSPSC:
12352111
NACRES:
NA.77
CHF 103.00
Spedizione prevista il28 maggio 2025
Prodotti consigliati
Livello qualitativo
Stato
solution
Produttore/marchio commerciale
Calbiochem®
Concentrazione
100 mg/mL in DMSO
Solubilità
DMSO: soluble
Temperatura di conservazione
2-8°C
Stringa SMILE
N1C(=O)CC(CC1=O)C[C@@H](O)[C@@H]2C[C@H](C[C@@H](C2=O)C)C
InChI
1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1
YPHMISFOHDHNIV-FSZOTQKASA-N
Descrizione generale
A convenient ready-to-use form of Cycloheximide (Cat. No. 239763). An anti-fungal antibiotic that inhibits protein synthesis in eukaryotes but not in prokaryotes. Interacts directly with the translocase enzyme, interfering with the translocation step. Also inhibits cell-free protein synthesis in eukaryotes. Competitively inhibits hFKBP12 (Ki = 3.4 µM). Triggers apoptosis in HL-60 cells, T-cell hybridomas, Burkitt′s lymphoma cells, and a variety of other cell types, including rodent macrophages. Induces DNA fragmentation in macrophages, but inhibits DNA cleavage in rat thymocytes treated with thapsigargin, methylprednisolone, and ionomycin. Rapidly destroyed in alkaline solutions.
Azioni biochim/fisiol
Primary Target
hFKBP12
hFKBP12
Confezionamento
Packaged under inert gas
Attenzione
Toxicity: Highly Toxic & Carcinogenic / Teratogenic (I)
Stato fisico
A 100 mg/ml solution of Cycloheximide (Cat. No. 239763) in DMSO (sterile-filtered).
Ricostituzione
Following initial use, aliquot and refrigerate (4°C).
Altre note
Christner, C., et al. 1999. J. Med. Chem.42, 3615.
Lu, Q. and Mellgreen,R.L. 1996. Arch. Biochem. Biophys.334, 175.
Chow, S.C., et al. 1995. Exp. Cell Res.216, 149.
Waring, P. 1990. J. Biol. Chem.265, 14476.
Obrig, T.G., et al. 1971. J. Biol. Chem.246, 174.
Pestka, S. 1971. Annu. Rev. Microbiol.25, 487.
Lu, Q. and Mellgreen,R.L. 1996. Arch. Biochem. Biophys.334, 175.
Chow, S.C., et al. 1995. Exp. Cell Res.216, 149.
Waring, P. 1990. J. Biol. Chem.265, 14476.
Obrig, T.G., et al. 1971. J. Biol. Chem.246, 174.
Pestka, S. 1971. Annu. Rev. Microbiol.25, 487.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Note legali
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Avvertenze
Danger
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Acute Tox. 3 Oral - Aquatic Chronic 3 - Muta. 2 - Repr. 1B
Codice della classe di stoccaggio
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Classe di pericolosità dell'acqua (WGK)
WGK 3
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