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C1988

Cicloesimide

Biotechnology Performance Certified

Sinonimo/i:

3-[2-(3,5-dimetil-2-ossocicloesil)-2-idrossietil]glutarimmide, Actidione, Naramicina A

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1 g
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CHF 116.00
5 g
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CHF 444.00

Informazioni su questo articolo

Formula empirica (notazione di Hill):
C15H23NO4
Numero CAS:
66-81-9
Peso molecolare:
281.35
UNSPSC Code:
51102829
NACRES:
NA.85
PubChem Substance ID:
24892457
EC Number:
200-636-0
Beilstein/REAXYS Number:
88868
MDL number:
MFCD00082346

CHF 116.00

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grade

Biotechnology Performance Certified

Quality Segment

200

form

powder

technique(s)

cell culture | mammalian: suitable

antibiotic activity spectrum

fungi, yeast

mode of action

protein synthesis | interferes

storage temp.

2-8°C

SMILES string

[H][C@]1(C[C@@H](C)C[C@H](C)C1=O)[C@H](O)CC2CC(=O)NC(=O)C2

InChI

1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1

InChI key

YPHMISFOHDHNIV-FSZOTQKASA-N

Gene Information

human ... FKBP1A(2280), PIN1(5300)

Application

Cycloheximide is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors. It has been shown to selectively clear macrophages in atherosclerotic plaques[1] and activate cumulus-free equine oocytes.[2]

Biochem/physiol Actions

Modalità d′azione: inibizione della traduzione negli eucarioti, che determina l′arresto della crescita cellulare e la morte cellulare. La CHX trova ampio impiego nella selezione dei ceppi di lieviti e funghi CHX-resistenti, nell′inibizione controllata della sintesi proteica finalizzata al rilevamento delle proteine a vita breve o alla superinduzione dell′espressione proteica, e nell′induzione o facilitazione dell′apoptosi ad opera dei recettori di morte.

Spettro d′azione: attivo contro lieviti e funghi come Candida, Aspergillus, Saccharomyces, Penicillium
Cycloheximide (CHX) is an antibiotic produced by S. griseus that inhibits protein biosynthesis in eukaryotes. It inactivate transferase II enzyme that is involved in peptide chain elongation.[3] More recent studies revealed that CHX binds the 60S ribosome and specifically prevents the translocation step in elongation.[4]

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research
Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

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Questo articolo
0181018079C4859
Cicloesimide Biotechnology Performance Certified

Sigma-Aldrich

C1988

Cicloesimide

Cycloheximide ≥95% (HPLC)

Sigma-Aldrich

01810

Cycloheximide

Cycloheximide solution 0.1%, suitable for microbiology

Millipore

18079

Cycloheximide solution

Cycloheximide solution Ready-Made Solution, microbial, 100 mg/mL in DMSO, Suitable for cell culture

Sigma-Aldrich

C4859

Cycloheximide solution

antibiotic activity spectrum

fungi, yeast

antibiotic activity spectrum

fungi, yeast

antibiotic activity spectrum

fungi

antibiotic activity spectrum

fungi, yeast

technique(s)

cell culture | mammalian: suitable

technique(s)

-

technique(s)

-

technique(s)

-

grade

Biotechnology Performance Certified

grade

-

grade

-

grade

-

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

300

form

powder

form

powder or crystals

form

liquid

form

ready-to-use solution

storage temp.

2-8°C

storage temp.

-

storage temp.

2-8°C

storage temp.

2-8°C

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Danger

Hazard Classifications

Acute Tox. 2 Oral - Aquatic Chronic 2 - Muta. 2 - Repr. 1B

Classe di stoccaggio

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificati d'analisi (COA)

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Questions

1–2 of 2 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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