212385-M

Carbachol

An unsubstituted carbamoyl ester that acts as an agonist for nicotinic and muscarinic acetylcholine receptors.

• Sinonimo/i: Carbachol, Carbamoylcholine Chloride
• Formula empirica (notazione di Hill): C₆H₁₅ClN₂O₂
• Numero CAS: 51-83-2
• Peso molecolare: 182.65
• Numero MDL: MFCD00012011
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (titration)
• Forma fisica: solid (fine crystalline)
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; desiccated (hygroscopic)
• Colore: white
• Solubilità: methanol: 100 mg/mL; water: 100 mg/mL; ethanol: 20 mg/mL
• Temperatura di conservazione: 10-30°C
• InChI: 1S/C6H14N2O2.ClH/c1-8(2,3)4-5-10-6(7)9;/h4-5H2,1-3H3,(H-,7,9);1H; AIXAANGOTKPUOY-UHFFFAOYSA-N

Descrizione

Descrizione generale

An unsubstituted carbamoyl ester that acts as an agonist for nicotinic and muscarinic acetylcholine receptors. Carbachol is totally resistant to the action of acetylcholine esterase (AChE) and non-specific cholinesterases. Inhibits apoptotic death of cultured granule neurons.

An unsubstituted carbamoyl ester that acts as an agonist for nicotinic and muscarinic acetylcholine receptors. Known to increase cytosolic Ca²⁺ and InsP₃ and decrease cAMP levels. Resistant to the action of acetylcholine esterase (AChE) and non-specific cholinesterases. Inhibits apoptotic death of cultured granule neurons.

Azioni biochim/fisiol

Primary Target
Agonist for nicotinic and muscarinic acetylcholine receptors

Attenzione

Toxicity: Highly Toxic (H)

Ricostituzione

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.

Altre note

Jence, M., et al. 1995. J. Neurochem. 64, 1605.
Yan, G.M., et al. 1995. Mol. Pharmacol. 47, 248.
Mangels, L.A., and Gnegy, M.E. 1992. J. Biol. Chem.267, 5847.
Watanabe, A.M., et al. 1992. In Basic and Clinical Pharmacology, Fifth Edition Katzung, B.G. ed.) Appleton and Lange, Norwalk, CT, p. 82.
Howe, P.H., et al. 1986. J. Pharmacol. Exp. Ther.239, 574.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Pittogrammi: GHS06
• Avvertenze: Danger
• Indicazioni di pericolo: H300
• Consigli di prudenza: P264 - P270 - P301 + P310 - P405 - P501
• Classi di pericolo: Acute Tox. 2 Oral
• Codice della classe di stoccaggio: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable