B2186

BL-1249

≥98% (HPLC)

• Sinonimo/i: (5,6,7,8-Tetrahydro-naphthalen-1-yl)-[2-(1H-tetrazol-5-yl)-phenyl]-amine
• Formula empirica (notazione di Hill): C₁₇H₁₇N₅
• Numero CAS: 18200-13-0
• Peso molecolare: 291.35
• NACRES: NA.77
• PubChem Substance ID: 24724415
• UNSPSC Code: 12352200
• MDL number: MFCD08276915
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: protect from light

Proprietà

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• storage condition: protect from light
• color: pink to brown
• solubility: DMSO: ~17.5 mg/mL, H₂O: insoluble
• storage temp.: −20°C
• SMILES string: C1CCc2c(C1)cccc2Nc3ccccc3-c4nnn[nH]4
• InChI: 1S/C17H17N5/c1-2-8-13-12(6-1)7-5-11-15(13)18-16-10-4-3-9-14(16)17-19-21-22-20-17/h3-5,7,9-11,18H,1-2,6,8H2,(H,19,20,21,22)
• InChI key: YYNRZIFBTOUICE-UHFFFAOYSA-N

Descrizione

General description

BL-1249 is a non-steroid anti-inflammatory drug and an inhibitor of the cyclooxygenase (COX) enzyme.[1]

Application

BL-1249 has been used:

• as an activator of mechano-gated K2P channel in contracted mouse ileum and colon tissues[1]
• as a TWIK related potassium channel (TREK2) modulator and in U-2 OS osteosarcoma cell line[2]
• as a TREK1 and TREK2 activator in mice.[3]

Biochem/physiol Actions

BL-1249 also activates TWIK related potassium channel 2 (TREK2). It interacts with K2P channel at the negatively charged activator site and modulates channel opening.[4]

BL-1249 is a potassium TREK-1 channel activator.

BL-1249 is a putative activator of potassium TREK-1 channel.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informazioni sulla sicurezza

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335,H413
• pcodes: P273 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Classe di stoccaggio: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves