A6419

Adenosina 5′-trifosfato

microbial, BioReagent, suitable for cell culture, ≥99% (HPLC)

• Sinonimo/i: ATP
• Formula empirica (notazione di Hill): C₁₀H₁₄N₅Na₂O₁₃P₃ · xH₂O
• Numero CAS: 34369-07-8
• Peso molecolare: 551.14 (anhydrous basis)
• Numero MDL: MFCD00150755
• Codice UNSPSC: 12352207
• eCl@ss: 32160414
• ID PubChem: 24891086
• NACRES: NA.75

Proprietà

• Origine biologica: microbial
• Livello qualitativo: 200
• Nome Commerciale: BioReagent
• Saggio: ≥99% (HPLC)
• Stato: powder
• tecniche: cell culture | mammalian: suitable
• Solubilità: H₂O: 50 mg/mL
• Temperatura di conservazione: −20°C
• Stringa SMILE: O.[Na+].[Na+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O
• InChI: 1S/C10H16N5O13P3.2Na.H2O/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20;;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);;;1H2/q;2*+1;/p-2/t4-,6-,7-,10-;;;/m1.../s1; NTBQNWBHIXNPRU-MSQVLRTGSA-L

Descrizione

Descrizione generale

Adenosine 5′-triphosphate (ATP) is essential for biological processes including neurotransmission, signal transduction, muscle contraction and cardiac function. ATP is the major energy potential for living systems.[1] They are released from cells under stress and play a key role in immune response.[2] ATP release from injured neurons and consequent breakdown leads to generation of adenosine.[3] ATP may serve as a therapeutic option in anaesthesia and intensive care medicine for the management of pain.[1] Elevated ATP levels are indicative of cell damage and inflammation.[4]

Applicazioni

Adenosine 5′-triphosphate disodium salt hydrate has been used:

• as a component of transfection mix for the transformation of CRISPR/Cas9 plasmid in parasites[5]
• in inflammasome activation assays in bone marrow derived macrophages[6]
• for the stimulation of macrophages[7]
• in nucleotide synthesis[8]

Azioni biochim/fisiol

Agonista dei purinocettori P₂.

Agonista purinergico P₂; aumenta l′attività dei canali K⁺ attivati da Ca²⁺; substrato per i sistemi enzimatici ATP-dipendenti

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Faceshields, Gloves, type N95 (US)