762040

Dibenzocyclooctyne-sulfo-N-hydroxysuccinimidyl ester

for Copper-free Click Chemistry

• Sinonimo/i: DBCO-sulfo-NHS ester, DBCO-sulfo-SE
• Formula empirica (notazione di Hill): C₂₅H₂₁N₂NaO₈S
• Peso molecolare: 532.50
• Numero MDL: MFCD22572669
• Codice UNSPSC: 12352108
• ID PubChem: 329766600
• NACRES: NA.22
• Stato: solid
• Saggio: ≥90.0 %

Proprietà

• Livello qualitativo: 100
• Saggio: ≥90.0 %
• Stato: solid
• Impiego in reazioni chimiche: reaction type: click chemistry; reagent type: linker
• P. ebollizione: 30 -100 °C
• Punto di fusione: 240-260 °C
• Solubilità: water: soluble at 20 °C
• Temperatura di conservazione: −20°C
• Stringa SMILE: O=C(CCCCC(ON(C(CC1S(=O)(O[Na])=O)=O)C1=O)=O)N2CC3=C(C=CC=C3)C#CC4=C2C=CC=C4
• InChI: 1S/C25H22N2O8S.Na/c28-22(11-5-6-12-24(30)35-27-23(29)15-21(25(27)31)36(32,33)34)26-16-19-9-2-1-7-17(19)13-14-18-8-3-4-10-20(18)26;/h1-4,7-10,21H,5-6,11-12,15-16H2,(H,32,33,34);/q;+1/p-1; QXKHPYSXPCJSPR-UHFFFAOYSA-M

Descrizione

Applicazioni

Water soluble succinimidyl ester/NHS functionalized cyclooctyne derivative for incorporation of the cyclooctyne moiety into amine containing compounds or biomolecules. Cyclooctynes are useful in strain-promoted copper-free azide-alkyne cycloaddition reactions. This dibenzocyclooctyne will react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage.

Dibenzocyclooctyne-sulfo-N-hydroxysuccinimidyl ester may be used for the covalent modification of nano-sized metal-organic frameworks (NMOFs) with nucleic acids via click chemistry during the synthesis stimuli-responsive DNA-gated NMOFs. These NMOFs can act as carriers of a fluorescent agent or anticancer drug, making them highly useful in targeted drug release system.[1]

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable