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220957

Sigma-Aldrich

Tilorone dihydrochloride

95%

Sinonimo/i:

2,7-Bis[2-(diethylamino)ethoxy]-9-fluorenone dihydrochloride

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100 MG
CHF 126.00

CHF 126.00

Spedizione prevista il29 maggio 2025

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100 MG
CHF 126.00

About This Item

Formula empirica (notazione di Hill):
C25H34N2O3 · 2HCl
Numero CAS:
27591-69-1
Peso molecolare:
483.47
Numero MDL:
MFCD00134071
Codice UNSPSC:
12352100
ID PubChem:
24853201
NACRES:
NA.22

CHF 126.00

Spedizione prevista il29 maggio 2025

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Saggio

95%

Punto di fusione

230-233 °C (lit.)

Gruppo funzionale

amine
ketone

Stringa SMILE

Cl[H].Cl[H].CCN(CC)CCOc1ccc2-c3ccc(OCCN(CC)CC)cc3C(=O)c2c1

InChI

1S/C25H34N2O3.2ClH/c1-5-26(6-2)13-15-29-19-9-11-21-22-12-10-20(30-16-14-27(7-3)8-4)18-24(22)25(28)23(21)17-19;;/h9-12,17-18H,5-8,13-16H2,1-4H3;2*1H
BSVYJQAWONIOOU-UHFFFAOYSA-N

Descrizione generale

Effect of tilorone dihydrochloride on the changes of transmembrane potential of mitochondrial membranes of the isolated rat hepatocytes has been investigated[1]. Tilorone dihydrochloride is an orally active, interferon-inducing antiviral agent[2].

Applicazioni

Tilorone dihydrochloride was used to study the interaction of drugs with synthetic self-complementary DNA by SPR (Surface Plasmon Resonance)[3].

Pittogrammi

Health hazardExclamation mark
GHS08,GHS07

Avvertenze

Warning

Classi di pericolo

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
MKCW4690
MKCW4689
MKCQ1148
MKCQ1147
MKCJ7818

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Chloroquine diphosphate salt powder or crystals, 98.5-101.0% (EP)

Sigma-Aldrich

C6628

Chloroquine diphosphate salt

C A Briggs et al.
British journal of pharmacology, 153(5), 1054-1061 (2007-12-25)
The alpha7 nicotinic acetylcholine receptor (nAChR) has attracted considerable interest as a target for cognitive enhancement in schizophrenia and Alzheimer's Disease. However, most recently described alpha7 agonists are derived from the quinuclidine structural class. Alternatively, the present study identifies tilorone
N V Kungurov et al.
Urologiia (Moscow, Russia : 1999), (5)(5), 46-52 (2011-01-25)
A total of 40 patients with non-gonococcal urethritis (NGU) were divided into two groups. Twenty patients of group 1 received standard antibacterial treatment while 20 patients of group 2 received the same treatment plus an immunotropic drug based on tiloron
V A Isakov et al.
Terapevticheskii arkhiv, 83(11), 44-47 (2012-02-09)
To assess efficacy of two-stage treatment of severe genital herpes (GH) with regular recurrences: combined use of antivirus medicines with interferon preparations and its inductors followed by antirecurrence vaccine therapy. Two-stage treatment was given to 100 patients suffering from GH
Tomoki Nishimura et al.
Biochemistry, 46(27), 8156-8163 (2007-06-19)
The fluorene derivative tilorone has received great attention as a DNA intercalator and has been widely recognized as an inducer of interferon. The biological activity of tilorone is known to be related to its binding mode with DNA; however, few
N M Zholobak et al.
Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 58(2), 39-43 (2012-08-10)
The influence of tilorone dihydrochloride and its analogues--diphenyl derivatives on the changes of transmembrane potential of mitochondrial membranes of the isolated rat hepatocytes has been estimated. Authors have shown a significant increase in mitochondrial potential thirty minutes after the introduction
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