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Merck

ESR2

estrogen receptor 2 (ER beta)

Sinonimi:
ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2
Specie:
ID UniProtKB:
ID gene:
  • Human(2100) Summary: This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]
  • Mouse(13983) estrogen receptor 2 (beta)
  • Rat(25149) estrogen receptor 2 (ER beta)
  • dog(403639) estrogen receptor 2 (ER beta)
  • chicken(395575) estrogen receptor 2 (ER beta)
  • domestic guinea pig(100731304) estrogen receptor 2 (ER beta)
  • Domestic Rabbit(100346748) estrogen receptor 2 (ER beta)
  • domestic cat(101086317) estrogen receptor 2 (ER beta)
  • Horse(100033964) estrogen receptor 2 (ER beta)
  • cow(281146) estrogen receptor 2 (ER beta)
  • Goat(100860823) estrogen receptor 2 (ER beta)
  • sheep(443066) estrogen receptor 2 (ER beta)

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Small Molecule - Activator

N° Catalogo
Descrizione
Specie
β-Nicotinamide adenine dinucleotide sodium salt, ,
Specie
human
β-Dinucleotide nicotinamide adenina, ≥95% (HPLC),
Specie
human
β-Nicotinamide adenine dinucleotide, pkg of 10 mg (per vial),
Specie
human
β-Dinucleotide nicotinamide adenina, ≥96.5% (HPLC), ≥96.5% (spectrophotometric assay), from yeast,
Specie
human
β-Nicotinamide adenine dinucleotide, pkg of 50 mg (per vial),
Specie
human

Small Molecule - Agonist

N° Catalogo
Descrizione
Specie
ERB-041, ≥98% (HPLC),
Specie
human
17α-Ethynylestradiol 3-cyclopentyl ether, ,
Specie
human
Estrone, ≥99%,
Specie
human, mouse, rat

Small Molecule - Allosteric Modulator

N° Catalogo
Descrizione
Specie
Raloxifene hydrochloride, United States Pharmacopeia (USP) Reference Standard,
Specie
human
Raloxifene hydrochloride, solid,
Specie
human
Estramustine sodium phosphate, ,
Specie
human
Raloxifene Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material,
Specie
human
Raloxifene hydrochloride, European Pharmacopoeia (EP) Reference Standard,
Specie
human

Small Molecule - Antagonist

N° Catalogo
Descrizione
Specie
Fulvestrant, >98% (HPLC),
Specie
human
2-Methoxyestradiol, powder,
Specie
human
Fulvestrant, United States Pharmacopeia (USP) Reference Standard,
Specie
human
Fulvestrant, European Pharmacopoeia (EP) Reference Standard,
Specie
human
Fulvestrant, European Pharmacopoeia (EP) Reference Standard,
Specie
human

Antibodies

N° Catalogo
Descrizione
Reattività con
Applicazione
Anti-Estrogen Receptor β Antibody, clone 68-4, rabbit monoclonal, clone 68-4, Upstate®, from rabbit,
Reattività con
human
Applicazione
immunoprecipitation (IP)
western blot
Monoclonal Anti-ESR2 antibody produced in mouse, ,
Reattività con
human, monkey, mouse
Applicazione
ChIP
dot blot

flow cytometry

immunocytochemistry

immunofluorescence

immunohistochemistry

western blot
Anti-Estrogen Receptor-β antibody produced in rabbit, affinity isolated antibody,
Reattività con
human, mouse, rat
Applicazione
ELISA
immunofluorescence

western blot
Anti-Estrogen Receptor β Antibody, clone 9.88, clone 9.88, from mouse,
Reattività con
human, mouse, rat
Applicazione
immunoprecipitation (IP)
western blot
Anti-ESR2 antibody produced in rabbit, affinity isolated antibody,
Reattività con
human
Applicazione
western blot

Cell Lines

N° Catalogo
Descrizione
Specie
MCF10A CELLS ESR2 (-/-), ,
Specie
human

Small Molecule - Mixed Agonist/Antagonist

N° Catalogo
Descrizione
Specie
α-Estradiol, powder, ≥98% (TLC),
Specie
human, rat
Estradiol, meets USP testing specifications,
Specie
human, mouse, rat
β-Estradiol, BioReagent, powder, suitable for cell culture,
Specie
human, mouse, rat
β-Estradiol, ≥98%,
Specie
human, mouse, rat
β-Estradiol, powder, γ-irradiated, suitable for cell culture,
Specie
human, mouse, rat

esiRNA

N° Catalogo
Descrizione
Specie
MISSION® esiRNA, targeting human ESR2,
Specie
human