E9750

Estrone

≥99% (HPLC), powder, estrogen receptor agonist

• Sinonimo/i: 1,3,5(10)-Estratrien-3-ol-17-one, 3-Hydroxy-1,3,5(10)-estratrien-17-one, Folliculin
• Formula empirica (notazione di Hill): C₁₈H₂₂O₂
• Numero CAS: 53-16-7
• Peso molecolare: 270.37
• Beilstein: 1915077
• Numero CE: 200-164-5
• Numero MDL: MFCD00003620
• Codice UNSPSC: 51111800
• ID PubChem: 24278427
• NACRES: NA.77

Proprietà

• Nome del prodotto: Estrone, ≥99%
• Origine biologica: synthetic (organic)
• Sterilità: non-sterile
• Saggio: ≥99%
• Stato: powder
• Punto di fusione: 258-260 °C (lit.)
• Solubilità: dioxane: 50 mg/mL, clear, colorless to very faintly yellow
• Condizioni di spedizione: ambient
• Temperatura di conservazione: room temp
• Stringa SMILE: C[C@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]1CCC2=O
• InChI: 1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16,19H,2,4,6-9H2,1H3/t14-,15-,16+,18+/m1/s1; DNXHEGUUPJUMQT-CBZIJGRNSA-N
• Informazioni sul gene: human ... ESR1(2099) , ESR2(2100) , ESRRA(2101) , ESRRB(2103) , HSD17B1(3292) , SERPINA6(866) ; mouse ... Esr1(13982) ; rat ... Esr1(24890)

Descrizione

Descrizione generale

Estrone is a weak form of estrogen and exists as estrone sulphate.[1] Estrone is a luteolytic estrogen produced by the corpus luteum.[2] In the follicle, estrone is synthesized from androstenedione by the action of cytochrome P450 aromatase.[3]

Applicazioni

Estrone has been used:

• as medium supplement for hormone based degranulation studies of natural killer cells[4]
• as an endocrine disrupting compound for screening bacterial biosensor in toxic water.[5]
• as medium component for monitoring fatty acid synthase (FASN) activity in breast adenocarcinoma cell lines[6]

Azioni biochim/fisiol

Estrone is an agonist for the estrogen receptor.[7] The estradiol to estrone interconversion is favourable in menopause.[7] Oral hormone replacement therapy (HRT) of estradiol-17β increases circulating levels of estrone.[8]

Caratteristiche e vantaggi

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS08
• Avvertenze: Danger
• Indicazioni di pericolo: H351,H360FD,H362
• Consigli di prudenza: P202 - P260 - P263 - P264 - P280 - P308 + P313
• Classi di pericolo: Carc. 2 - Lact. - Repr. 1A
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges