T2752

3,3′,5-Triiod-L-thyronin Natriumsalz

≥95% (HPLC)

• Synonym(e): O-(4-Hydroxy-3-iodphenyl)-3,5-diiod-L-tyrosin Natriumsalz, Liothyronin, T₃
• Empirische Formel (Hill-System): C₁₅H₁₁I₃NNaO₄
• CAS-Nummer: 55-06-1
• Molekulargewicht: 672.96
• Beilstein: 8179867
• EG-Nummer: 200-223-5
• MDL-Nummer: MFCD00002594
• UNSPSC-Code: 51111800
• PubChem Substanz-ID: 24900071
• NACRES: NA.32

Eigenschaften

• Biologische Quelle: synthetic (organic)
• Assay: ≥95% (HPLC)
• Form: powder
• Methode(n): cell culture | mammalian: suitable
• Löslichkeit: ethanol/1 M HCl (4:1): 10 mg/mL, clear, colorless to faintly yellow or pink
• Versandbedingung: ambient
• Lagertemp.: −20°C
• SMILES String: [Na+].N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C([O-])=O
• InChI: 1S/C15H12I3NO4.Na/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22;/h1-4,6,12,20H,5,19H2,(H,21,22);/q;+1/p-1/t12-;/m0./s1
• InChIKey: SBXXSUDPJJJJLC-YDALLXLXSA-M
• Angaben zum Gen: human ... THRA(7067) , THRB(7068) ; rat ... Thra(81812) , Thrb(24831)

Beschreibung

Anwendung

3,3′,5-Triiodo-L-thyronine sodium salt was used in Oligodendrocyte differentiation medium used for isolation and culture of rat and mouse oligodendrocyte precursor cells. The product was used as a test compound for incubating adipocyte cells, used for studying the impact of hormones and butyrate on modulation of porcine adipocyte beta-adrenergic receptors.

Biochem./physiol. Wirkung

3,3′,5-Triiodo-L-thyronine also referred to as O-(4-Hydroxy-3-iodophenyl)−3,5−diiodo-L-tyrosine sodium salt or T3 is the biologically active thyroid hormone. In hypothyroidism pateints, triiodothyronine can enhance mood and neuropsychological function. The product also positively regulates the hepatic FGF21 expression and stimulates the metabolic breakdown of glucose, fats, and proteins by enhancing the levels of numerous metabolic enzymes such as hexokinase, liver glucose 6-phosphatase as well as mitochondrial enzymes for oxidative phosphorylation.

Angaben zur Herstellung

3,3′,5-Triiodo-L-thyronine sodium salt dissolves in 1 M HCl:EtOH with a ratio of 1:4 at 10 mg/ml to yield a clear, colorless to yellow or faint pink solution.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)