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T0699

Sigma-Aldrich

Trichloressigsäure -Lösung

6.1 N

Synonym(e):

TCA

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About This Item

Lineare Formel:
Cl3CCOOH
CAS-Nummer:
76-03-9
Molekulargewicht:
163.39
Beilstein:
970119
MDL-Nummer:
MFCD00004177
UNSPSC-Code:
12352106
PubChem Substanz-ID:
57654645
NACRES:
NA.26

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Form

liquid

Konzentration

6.1 N
~100 % (w/v)

SMILES String

OC(=O)C(Cl)(Cl)Cl

InChI

1S/C2HCl3O2/c3-2(4,5)1(6)7/h(H,6,7)

InChIKey

YNJBWRMUSHSURL-UHFFFAOYSA-N

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Allgemeine Beschreibung

Trichloressigsäure (TCA) ist eine starke Säure. Beim pH-Wert von Trinkwasser existiert TCA fast in Salzform.

Anwendung

Trichloressigsäurelösung wird wie folgt verwendet:
  • im Indolamin-2,3-dioxygenase(IDO)-Enzymassay für die Hydrolyse von N-Formylkynurenin und zum Herstellen von Kynurenin
  • bei der Proliferation von glatten Muskelzellen von humanen Lungenarterien (HPASMC)
  • zum Behandeln von Grundgewebe und Ausfällungen von Proteinen während der Proteinextraktion und -quantifizierung

Biochem./physiol. Wirkung

Trichloressigsäure (TCA) ohne bekannte systemische Toxizität wird als bewährtes Mittel für oberflächliche Peelings eingesetzt. Sie ist ein Peroxisomproliferator.
Trifluoressigsäurelösung wird traditionell zum Ausfällen von Proteinen eingesetzt. Sie kann zum Bestimmen der Proteinkonzentration durch quantitative Ausfällung eingesetzt werden. Trifluoressigsäure kann auch als Entkalker und Fixiermittel in der Mikroskopie verwendet werden.

Signalwort

Danger

Gefahreneinstufungen

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1A - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

8A - Combustible corrosive hazardous materials

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000341709
0000332300
0000295050
0000332300
0000341709

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Guillaume Laflamme et al.
Cell reports, 26(11), 2875-2889 (2019-03-14)
The segregation of chromosomes is a critical step during cell division. This process is driven by the elongation of spindle microtubules and is tightly regulated by checkpoint mechanisms. It is unknown whether microtubules affect checkpoint responses as passive contributors or
Alan Mortensen et al.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 18(1), 55-62 (2012-10-17)
The ratio of the nitric oxide synthase (NOS) cofactor tetrahydrobiopterin (BH(4)) to its oxidized form dihydrobiopterin (BH(2)) has been suggested as an index of endothelial dysfunction. Consequently, much effort has been put into preserving the in vivo equilibrium between these
Hikmat Al-Ahmadie et al.
Cancer discovery, 4(9), 1014-1021 (2014-06-18)
Metastatic solid tumors are almost invariably fatal. Patients with disseminated small-cell cancers have a particularly unfavorable prognosis, with most succumbing to their disease within two years. Here, we report on the genetic and functional analysis of an outlier curative response
Valentina Folgiero et al.
Oncotarget, 5(8), 2052-2064 (2014-06-07)
Microenvironmental factors contribute to the immune dysfunction characterizing acute myeloid leukemia (AML). Indoleamine 2,3-dioxygenase 1 (IDO1) is an interferon (IFN)-γ-inducible enzyme that degrades tryptophan into kynurenine, which, in turn, inhibits effector T cells and promotes regulatory T-cell (Treg) differentiation. It
Makoto Yamagishi et al.
Scientific reports, 5, 17868-17868 (2015-12-08)
Biological robustness is exposed to stochastic perturbations, which should be controlled by intrinsic mechanisms; the promiscuous signaling network without appropriate alleviation is the true nature of cancer cells. B cell receptor (BCR) signaling is a major source of gene expression
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Protokolle

Enzymatic Activity of Glucose-6-Phosphatase [EC 3.1.3.9]

To measure glucose-6-phosphatase activity, the Taussky-Shorr method is used. This method is a spectrophotometric stop-rate determination assay that is measured at 660 nm.

Enzymatic Assay of Pepsin (3.4.23.1)

This procedure may be used for determination of Pepsin activity using hemoglobin as the substrate. It is a spectrophotometric stop rate determination.

Enzymatic Assay of Amyloglucosidase (EC 3.2.1.3)

This procedure may be used for the determination of Amyloglucosidase activity using starch as the substrate.

Proteinase K Enzymatic Assay

Proteinase K activity measured via spectrophotometry using hemoglobin substrate, crucial for enzyme characterization.

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Questions

1–2 of 2 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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