T0442

Anti-phospho-Tyk2 (pTyr^1054/1055) antibody produced in rabbit

affinity isolated antibody, buffered aqueous glycerol solution

• MDL-Nummer: MFCD02097177
• UNSPSC-Code: 12352203
• NACRES: NA.44

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 200
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous glycerol solution
• Mol-Gew.: 134 kDa
• Speziesreaktivität: human
• Methode(n): western blot: 1:1000
• UniProt-Hinterlegungsnummer: P29597
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Angaben zum Gen: human ... TYK2(7297)

Beschreibung

Allgemeine Beschreibung

Tyk2 is a member of the Jak family of protein tyrosine kinases. It associates with and is activated by
receptors for many cytokines including IL-13, the IL-6 family, IL-10, and IFN-a and β. Following ligand binding,
Tyk2 is activated by phosphorylation of Tyr1054 and/or Tyr1055. Tyk2 is required for the tyrosine phosphoryla-
tion of Stat3 in the IFN-β signaling cascade.

Spezifität

Detects human Tyk2 only when phosphorylated at Tyr^1054/1055.

Immunogen

synthetic phospho-Tyr^1054/1055 peptide corresponding to residues around Tyr^1054/1055 of human Tyk2.

Physikalische Form

Solution in 10 mM sodium HEPES, pH 7.5, containing 150 mM sodium chloride, 100 μg/ml bovine serum albumin and 50% glycerol

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable