SML3716

MS6105

≥98% (HPLC)

• Synonym(e): 2-(5-(Cyclopropylmethyl)-3-(3-(6-(13-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-13-oxotridecanamido)hex-1-yn-1-yl)phenyl)-4-(4-sulfamoylbenzyl)-1H-pyrazol-1-yl)thiazole-4-carboxylic acid
• Empirische Formel (Hill-System): C₆₅H₈₁N₉O₉S₃
• CAS-Nummer: 2891709-58-1
• Molekulargewicht: 1228.59
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear (Warmed)
• Lagertemp.: -10 to -25°C
• SMILES String: O=C(NCCCCC#CC1=CC(C2=NN(C(CC3CC3)=C2CC4=CC=C(C=C4)S(N)(=O)=O)C5=NC(C(O)=O)=CS5)=CC=C1)CCCCCCCCCCCC(N[C@H](C(N6C[C@@H](C[C@H]6C(NCC7=CC=C(C=C7)C8=C(N=CS8)C)=O)O)=O)C(C)(C)C)=O
• InChI: 1S/C65H81N9O9S3/c1-43-59(85-42-69-43)48-30-26-47(27-31-48)39-68-61(78)55-38-50(75)40-73(55)62(79)60(65(2,3)4)71-57(77)23-16-11-9-7-5-6-8-10-15-22-56(76)67-34-17-13-12-14-19-44-20-18-21-49(35-44)58-52(36-45-28-32-51(33-29-45)86(66,82)83)54(37-46-24-25-46)7
• InChIKey: APEYSKGQWJKJAZ-LCLGPXMOSA-N

Beschreibung

Biochem./physiol. Wirkung

Cell penetrant, potent and selective lactate dehydrogenase (LDH) degrader (PROTAC) that effectively degrades LDHA and LDHB in PANC1 cells

MS6105 is a cell penetrant, potent and selective lactate dehydrogenase (LDH) degrader (PROTAC) that effectively degrades LDHA and LDHB in multiple pancreatic cancer cell lines. MS6105 potently inhibits the proliferation of PANC1 cells.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable