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Dokumente

SML2891

Sigma-Aldrich

M871 trifluoroacetate

≥95% (HPLC)

Synonym(e):

Galanin-(2-13)-Glu-His-(Pro)3-(Ala-Leu)2-Ala-amide, TFA salt, M 871, TFA salt, M-871, TFA salt, Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Glu-His-Pro-Pro-Pro-Ala-Leu-Alal-Leu-Ala-NH2, TFA salt, WTLNSAGYLLGPEHPPPALALA-NH2, TFA salt

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About This Item

Empirische Formel (Hill-System):
C108H163N27O28 · xC2HF3O2
Molekulargewicht:
2287.61 (free base basis)
UNSPSC-Code:
12352200
NACRES:
NA.77

Qualitätsniveau

100

Assay

≥95% (HPLC)

Form

lyophilized powder

Farbe

white to off-white

Lagertemp.

−20°C

Biochem./physiol. Wirkung

M871 is a type 2-selective galanin receptor antagonist (GalR2/GalR1 Ki = 13.1/410 nM by competitive binding against 0.1 nM porcine galanin using membranes from CHO expressing respective human receptors; GalR2/GalR1 Ki = 2.5/1.1 nM in case of rat galanin) that potently blocks 10 nM rat galanin-induced inositol phosphate production in human GalR2-expressing CHO cells (by 100% with 0.1, 1 or 10 nM M871). M871 is widely employed in cultures (0.1 nM-2.5 μM) and in mice and rats in vivo via ip., brain region- or other site-specific injections.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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M871-A Novel Peptide Antagonist Selectively Recognizing the Galanin Receptor Type 2
Sollenberg UE, Lundstrom L, Bartfai T, Langel U
International Journal of Peptide Research and Therapeutics, 12, 115-119 (2006)
Pawel A Kolodziejski et al.
Biochimica et biophysica acta. Molecular and cell biology of lipids, 1863(10), 1228-1236 (2018-10-12)
Spexin (SPX, NPQ) is a novel peptide involved in the regulation of energy metabolism. SPX inhibits food intake and reduces body weight. In obese humans, SPX is the most down-regulated gene in fat. Therefore, SPX might be involved in the
Mayara Machado de Souza et al.
Neuroscience letters, 681, 26-30 (2018-05-23)
Galanin is a neuropeptide distributed in human and rat brain regions that are involved with emotional regulation, such as the dorsal raphe nucleus (DRN). Galanin effects in the DRN are mediated by GAL1 and GAL2 receptors. Intracerebral infusion of a
Seu-Hwa Chen et al.
PloS one, 13(6), e0199512-e0199512 (2018-06-22)
In this study, we investigated temporal changes in galanin receptor type 2 (GalR2) expression in NF200-, galanin-, neuropeptide Y (NPY)-, and neuronal nitric oxide synthase (nNOS)-like immunoreactive (LI) dorsal root ganglion (DRG) neurons after median nerve chronic constriction injury (CCI)
Jesus-Servando Medel-Matus et al.
Experimental neurology, 289, 64-72 (2016-12-26)
Status epilepticus (SE) in rats, along with chronic epilepsy, leads to the development of behavioral impairments resembling depressive disorder and/or attention deficit/hyperactivity disorder (ADHD), thus reflecting respective comorbidities in epilepsy patients. Suppressed neurotransmitter tone in the raphe nucleus (RN)-prefrontal cortex
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