SML1507

CRT0066101 hydrochloride

≥98% (HPLC)

• Synonym(e): 2-[4-((R)-2-Amino-butylamino)-pyrimidin-2-yl]-4-(1-methyl-1Hpyrazol-4-yl)-phenol hydrochloride, 2-[4-[[(2R)-2-Aminobutyl]amino]-2-pyrimidinyl]-4-(1-methyl-1H-pyrazol-4-yl)-phenol hydrochloride
• Empirische Formel (Hill-System): C₁₈H₂₂N₆O · xHCl
• CAS-Nummer: 956123-34-5
• Molekulargewicht: 338.41 (free base basis)
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: H₂O: 15 mg/mL, clear
• Lagertemp.: −20°C
• SMILES String: Cl.[n]1(ncc(c1)c2cc(c(cc2)O)c3nc(ccn3)NC[C@H](N)CC)C
• InChI: 1S/C18H22N6O.ClH/c1-3-14(19)10-21-17-6-7-20-18(23-17)15-8-12(4-5-16(15)25)13-9-22-24(2)11-13;/h4-9,11,14,25H,3,10,19H2,1-2H3,(H,20,21,23);1H/t14-;/m1./s1
• InChIKey: NBKRZGHHBBHLOQ-PFEQFJNWSA-N

Beschreibung

Biochem./physiol. Wirkung

CRT0066101 is a very potent inhibitor of Protein Kinase D (PKD) isoforms with IC₅₀ values for PKD-1, -2 and -3 = 1, 2.5 and 2 nM, respecitively. CRT0066101 has been shown to have anticancer activity. CRT0066101 potently inhibits proliferation of PANC-1 pancreatic cells, and blocks migration and invasion of U87MG glioblastoma cells. CRT0066101 has also been shown to decrease growth of primary tumors and metastasis of ER(-) breast cancers.

CRT0066101 is a very potent inhibitor of Protein Kinase D (PKD) isoforms.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable