SML1162

5-Fluoro-1-propargyl-uracil

≥98% (HPLC)

• Synonym(e): 1-Propargyl-5-fluorouracil, 5-Fluoro-1-(2-propyn-1-yl)-2,4(1H,3H)-pyrimidinedione
• Empirische Formel (Hill-System): C₇H₅FN₂O₂
• CAS-Nummer: 69849-33-8
• Molekulargewicht: 168.13
• MDL-Nummer: MFCD18364451
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825692
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: H₂O: 1 mg/mL, clear (warmed)
• Lagertemp.: 2-8°C
• SMILES String: O=C1C(F)=CN(CC#C)C(N1)=O
• InChI: 1S/C7H5FN2O2/c1-2-3-10-4-5(8)6(11)9-7(10)12/h1,4H,3H2,(H,9,11,12)
• InChIKey: GMCOGJQJFDQZCP-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

5-Fluoro-1-propargyl-uracil is a biologically inert precursor, a prodrug that can be bioorthogonally activated to 5-fluorouracil iside a tumor that has a previously implanted palladium catalyst. Preliminary tests with pancreatic and colorectal cancer cells resulted in the death of than 80% of the malignant cells.

5-Fluoro-1-propargyl-uracil is a biologically inert precursor, a prodrug that can be bioorthogonally activated to 5-fluorouracil.

Leistungsmerkmale und Vorteile

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable