SML1113

RSC133

≥98% (HPLC)

• Synonym(e): 3-[[(2E)-3-(1H-Indol-3-yl)-1-oxo-2-propen-1-yl]amino]-benzamide, RSC 133, Reprogramming stimulating compound 133
• Empirische Formel (Hill-System): C₁₈H₁₅N₃O₂
• CAS-Nummer: 1418131-46-0
• Molekulargewicht: 305.33
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825654
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: protect from light
• Farbe: white to light brown
• Löslichkeit: DMSO: 20 mg/mL, clear
• Lagertemp.: −20°C
• SMILES String: NC(C1=CC=CC(NC(/C=C/C2=CNC3=C2C=CC=C3)=O)=C1)=O
• InChI: 1S/C18H15N3O2/c19-18(23)12-4-3-5-14(10-12)21-17(22)9-8-13-11-20-16-7-2-1-6-15(13)16/h1-11,20H,(H2,19,23)(H,21,22)/b9-8+
• InChIKey: HYUDSQGICKAEGE-CMDGGOBGSA-N

Beschreibung

Biochem./physiol. Wirkung

RSC133 is an epigenetic modulator that effectively enhances reprogramming of human somatic cells and maintenance of human stem cell pluripotency.

RSC133 is an epigenetic modulator that effectively enhances reprogramming of human somatic cells and maintenance of human stem cell pluripotency. Apparently, RSC133 facilitates the reprograming by dual inhibition of histone deacetylase and DNA methyltransferase activities. In hFFs, RSC133 rapidly activates pluripotency-associated genes Nanog, Oct4, and Rex1 up to 2- to 2.5-fold. RSC133 exerts positive effects on cell proliferation and ablates pro-senescence phenotypes.

Leistungsmerkmale und Vorteile

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Sonstige Hinweise

Light sensitive

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable