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SML0060

Sigma-Aldrich

NB001

≥98% (HPLC)

Synonym(e):

5-[[2-(6-Amino-9H-purin-9-yl)ethyl]amino]-1-pentanol; HTS 09836

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About This Item

Empirische Formel (Hill-System):
C12H20N6O
CAS-Nummer:
686301-48-4
Molekulargewicht:
264.33
MDL-Nummer:
MFCD03086724
UNSPSC-Code:
41106305
PubChem Substanz-ID:
329825126
NACRES:
NA.77

Assay

≥98% (HPLC)

Form

powder

Farbe

white to tan

Löslichkeit

H2O: ≥24 mg/mL

Lagertemp.

−20°C

SMILES String

Nc1ncnc2n(CCNCCCCCO)cnc12

InChI

1S/C12H20N6O/c13-11-10-12(16-8-15-11)18(9-17-10)6-5-14-4-2-1-3-7-19/h8-9,14,19H,1-7H2,(H2,13,15,16)

InChIKey

CVPTTZZCRDVGSU-UHFFFAOYSA-N

Anwendung

NB001 may be used in adenylyl cyclase 1-mediated cell signaling studies.

Biochem./physiol. Wirkung

NB001, originally believed to be a selective inhibitor of adenylyl cyclase 1 (AC1), new evidence suggests NB001 does not interact with AC1 directly. NB001 may reduce cAMP accumulation in cells through an unknown mechanism that is dependent on AC1.

Leistungsmerkmale und Vorteile

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Adenylyl cyclases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Piktogramme

Skull and crossbones
GHS06

Signalwort

Danger

H-Sätze

H301

Gefahreneinstufungen

Acute Tox. 3 Oral

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

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Elizabeth Stanley Shepherd et al.
Nature, 557(7705), 434-438 (2018-05-11)
The dense microbial ecosystem in the gut is intimately connected to numerous facets of human biology, and manipulation of the gut microbiota has broad implications for human health. In the absence of profound perturbation, the bacterial strains that reside within
Sung-Chul Lim et al.
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 21(4), 397-405 (2017-07-15)
MDL-12330A is a widely used adenylyl cyclase (AC) inhibitor that blocks AC/cAMP signaling. In this study, we demonstrated a novel antitumor activity of this drug in gastric carcinoma (GC) cell lines. In these GC cells, MDL-12330A reduced cell viability and
Kelly E Bosse et al.
The Journal of pharmacology and experimental therapeutics, 363(2), 148-155 (2017-08-26)
Neuroadaptive responses to chronic ethanol, such as behavioral sensitization, are associated with
Ryan B Griggs et al.
Neurobiology of disease, 127, 76-86 (2019-02-27)
Painful diabetic neuropathy (PDN) is a devastating neurological complication of diabetes. Methylglyoxal (MG) is a reactive metabolite whose elevation in the plasma corresponds to PDN in patients and pain-like behavior in rodent models of type 1 and type 2 diabetes.
Shui-Bing Liu et al.
Journal of neurochemistry, 153(2), 252-263 (2019-10-31)
Cortical areas including the anterior cingulate cortex (ACC) play critical roles in different types of chronic pain. Most of previous studies focus on the sensory inputs from somatic areas, and less information about plastic changes in the cortex for visceral
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Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.

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