SAB4502906

Anti-Synaptophysin antibody produced in rabbit

affinity isolated antibody

• Synonym(e): major synaptic vesicle protein p38, synaptophysin
• MDL-Nummer: MFCD00164741
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: antigen 33 kDa
• Speziesreaktivität: mouse, rat, human
• Konzentration: ~1 mg/mL
• Methode(n): ELISA: 1:10000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI-Hinterlegungsnummer: P08247
• UniProt-Hinterlegungsnummer: P08247
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... SYP(6855)

Beschreibung

Allgemeine Beschreibung

Synaptophysin (SYP) is an integral membrane protein of synaptic vesicles. It is expressed in cortical synaptic terminals, during neurogenesis. The gene is located on human chromosome Xp11.23.

Synaptophysin is an integral membrane glycoprotein that is localized in presynaptic vesicles of nerve cells. This protein may regulate exocytosis and the formation of synaptic vesicles . Synaptophysin is encoded by the SYP gene and genetic alterations in SYP can lead to mental retardation . Anti-synaptophysin antibody specifically detects endogenous levels of total synaptophysin protein.

Immunogen

The antiserum was produced against synthesized peptide derived from human Synaptophysin.

Immunogen Range: 101-150

Anwendung

Anti-Synaptophysin antibody produced in rabbit has been used in:

• immunocytochemistry
• western blotting
• immunohistochemistry

Anti-synaptophysin antibody is suitable for use in immunohistochemistry and western blot.

Biochem./physiol. Wirkung

Synaptophysin (SYP) modulates neurotransmitter release and synaptic plasticity. It maintains biogenesis and recycling of synaptic vesicles. SYP functions as a marker for neuroendocrine tumors. It is used as a potent marker for neuroendocrine prostate cancer (NEPC). Mutations in this gene is associated with X-linked intellectual disability.

Leistungsmerkmale und Vorteile

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Physikalische Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: nwg
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable