R8756

Resiniferatoxin aus a T-cell leukemic cell line

from Euphorbia poisonii, ~95%

• Empirische Formel (Hill-System): C₃₇H₄₀O₉
• CAS-Nummer: 57444-62-9
• Molekulargewicht: 628.71
• Beilstein: 5371150
• MDL-Nummer: MFCD00135927
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24899411

Eigenschaften

• Biologische Quelle: Euphorbia poisonii
• Qualitätsniveau: 100
• Assay: ~95%
• Lagertemp.: −20°C
• SMILES String: [H][C@@]12C=C(C)C(=O)[C@@]1(O)CC(COC(=O)Cc3cc(O)cc(OC)c3)=CC4[C@H]5O[C@]7(Cc6ccccc6)O[C@]5(C[C@@H](C)[C@]24O7)C(C)=C
• InChI: 1S/C37H40O9/c1-21(2)35-17-23(4)37-29(33(35)44-36(45-35,46-37)19-24-9-7-6-8-10-24)14-26(18-34(41)30(37)11-22(3)32(34)40)20-43-31(39)15-25-12-27(38)16-28(13-25)42-5/h6-14,16,23,29-30,33,38,41H,1,15,17-20H2,2-5H3/t23-,29?,30-,33-,34-,35-,36-,37-/m1/s1
• InChIKey: IKYCZSUNGFRBJS-PMIKMUNESA-N
• Angaben zum Gen: rat ... Trpv1(83810)

Beschreibung

Anwendung

Resiniferatoxin has been used as an agonist to transient receptor potential vanilloid 2 (TRPV2):

• for complex preparation for cryo-electron microscopy structural studies[1]
• to test its effect towards immune responses to P. aeruginosa in sensory neurons associated with the cornea[2]
• to study its effects in the denervation of the peripheral sensory nerves in psoriatic mice[3]

Biochem./physiol. Wirkung

Potent VR1 vanilloid receptor agonist that has been used to label the vanilloid receptor in sensory ganglia; activates protein kinase C. Diterpene ester that is related to phorbol, but is not tumorigenic.

Potent VR1 vanilloid receptor agonist.

Resiniferatoxin (RTX) is an analog of capsaicin. It effectively ablates corneal sensory neurons by activating transient receptor potential vanilloid 1 (TRPV1) channels. RTX facilitates corneal bacterial clearance.[2] It also elicits protective functionality towards cardiac function in a rat model with congestive heart failure (CHF).[4]

Sicherheitshinweise

• Piktogramme: GHS06,GHS05
• Signalwort: Danger
• H-Sätze: H301,H314
• P-Sätze: P260 - P280 - P301 + P310 + P330 - P301 + P330 + P331 - P303 + P361 + P353 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 3 Oral - Skin Corr. 1A
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges