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P4651

Sigma-Aldrich

Promethazin -hydrochlorid

Synonym(e):

10-[2-(Dimethylamino)-propyl]-phenothiazin -hydrochlorid

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About This Item

Empirische Formel (Hill-System):
C17H20N2S · HCl
CAS-Nummer:
58-33-3
Molekulargewicht:
320.88
Beilstein:
4166397
EG-Nummer:
200-375-2
MDL-Nummer:
MFCD00012652
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24277802
NACRES:
NA.77

Form

powder

Ersteller

Wyeth

SMILES String

Cl[H].CC(CN1c2ccccc2Sc3ccccc13)N(C)C

InChI

1S/C17H20N2S.ClH/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19;/h4-11,13H,12H2,1-3H3;1H

InChIKey

XXPDBLUZJRXNNZ-UHFFFAOYSA-N

Angaben zum Gen

human ... HRH1(3269)

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Biochem./physiol. Wirkung

H1 histamine receptor antagonist; CNS depressant; anticholinergic.

Leistungsmerkmale und Vorteile

This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sonstige Hinweise

Solubility: Freely soluble in water, in hot dehydrated alcohol and in Chloroform. Practically insoluble in ether, in acetone and in ethyl acetate.

Physikalische Form

Appearance: White or faint yellow, odorless, Crystalline powder, slowly oxidizes and acquires a blue color, on prolonged exposure to air.

Anwendung

Produkt-Nr.
Beschreibung
Preisangaben

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Analysenzertifikate (COA)

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A B Wright et al.
Ultrasound in medicine & biology, 25(2), 241-247 (1999-05-13)
This sonographic study was aimed at examining the effect of sedation with promethazine (1.5 mg x kg(-1)), on gastroduodenal function in neonatal piglets. On 3 consecutive days, observations of gastroduodenal motility during the first 3 postprandial h were made in
Z Li et al.
Neuroscience, 70(1), 145-158 (1996-01-01)
Ionic mechanisms responsible for histamine-induced prolonged depolarization in supraoptic nucleus neurons were investigated using whole-cell patch recordings in horizontally prepared brain slices from adult male rats. Bath application of histamine (1-10 microM) in control medium induced membrane depolarization in nine
Frank Fasbender et al.
Archives of toxicology, 94(2), 439-448 (2020-02-16)
Drug-induced liver injury (DILI) represents one of the major causes why drugs have to be withdrawn from the market. In this study, we describe a new interaction between drug-exposed hepatocytes and natural killer (NK) cells. In a previous genome-wide expression
Louis C Leung et al.
Nature, 571(7764), 198-204 (2019-07-12)
Slow-wave sleep and rapid eye movement (or paradoxical) sleep have been found in mammals, birds and lizards, but it is unclear whether these neuronal signatures are found in non-amniotic vertebrates. Here we develop non-invasive fluorescence-based polysomnography for zebrafish, and show-using unbiased, brain-wide
William C Kwan et al.
The Journal of comparative neurology, 527(3), 558-576 (2018-01-03)
The primate visual brain possesses a myriad of pathways, whereby visual information originating at the retina is transmitted to multiple subcortical areas in parallel, before being relayed onto the visual cortex. The dominant retinogeniculostriate pathway has been an area of
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Chromatograms

application for HPLC

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