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M6545

Sigma-Aldrich

Mitoxantron -dihydrochlorid

≥97% (HPLC)

Synonym(e):

1,4-Dihydroxy-5,8-bis-[[2-[(2-hydroxyethyl)-amino]-ethyl]-amino]-9,10-anthracendion -dihydrochlorid

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About This Item

Empirische Formel (Hill-System):
C22H28N4O6 · 2HCl
CAS-Nummer:
70476-82-3
Molekulargewicht:
517.40
EG-Nummer:
274-619-1
MDL-Nummer:
MFCD00242943
UNSPSC-Code:
12352005
PubChem Substanz-ID:
24278562
NACRES:
NA.25

Assay

≥97% (HPLC)

SMILES String

Cl[H].Cl[H].OCCNCCNc1ccc(NCCNCCO)c2C(=O)c3c(O)ccc(O)c3C(=O)c12

InChI

1S/C22H28N4O6.2ClH/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32;;/h1-4,23-30H,5-12H2;2*1H

InChIKey

ZAHQPTJLOCWVPG-UHFFFAOYSA-N

Angaben zum Gen

human ... TOP2A(7153)

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Anwendung

Mitoxantrone dihydrochloride has been used:
  • to induce calreticulin surface expression in cells
  • as a genotoxin agent
  • as a topoisomerase inhibitor

Biochem./physiol. Wirkung

Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. Mitoxantrone also displays broad immunosuppressive activity inhibiting proliferation of all classes of lymphocytes and inducing apoptosis of antigen-presenting T cells. It used clinically as a chemotherapeutic agent against leukemias and solid tumors and as an immune system modulator in multiple sclerosis.

Piktogramme

Health hazard
GHS08

Signalwort

Danger

H-Sätze

H340,H360

Gefahreneinstufungen

Muta. 1B - Repr. 1B

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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