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Merck

P1138

Sigma-Aldrich

1,2-Distearoyl-sn-Glycero-3-Phosphocholin

≥99%

Synonym(e):

PC, 1,2-Dioctadecanoyl-sn-glycero-3-phosphocholin, 3-sn-Phosphatidylcholin, 1,2-distearoyl, L-β,γ-Distearoyl-α-lecithin, DSPC, PC(18:0/18:0)

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100 MG
CHF 98.30
250 MG
CHF 168.00
1 G
CHF 437.00
5 G
CHF 2’020.00

CHF 98.30


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100 MG
CHF 98.30
250 MG
CHF 168.00
1 G
CHF 437.00
5 G
CHF 2’020.00

About This Item

Empirische Formel (Hill-System):
C44H88NO8P
CAS-Nummer:
Molekulargewicht:
790.15
Beilstein:
3923978
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
12352211
PubChem Substanz-ID:
NACRES:
NA.25

CHF 98.30


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Biologische Quelle

semisynthetic

Assay

≥99%

Form

powder

Funktionelle Gruppe

phospholipid

Lipid-Typ

phosphoglycerides

Versandbedingung

ambient

Lagertemp.

−20°C

SMILES String

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O)=O

InChI

1S/C44H88NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-43(46)50-40-42(41-52-54(48,49)51-39-38-45(3,4)5)53-44(47)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h42H,6-41H2,1-5H3/t42-/m1/s1

InChIKey

NRJAVPSFFCBXDT-HUESYALOSA-N

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Allgemeine Beschreibung

Nicht-pyrogene, eindeutig definierte Liposomen, beladen mit einem beliebigen Molekül, werden mit einem einzigen Hydrationsschritt gebildet.

Anwendung


  • Amantadine interactions with phase separated lipid membranes.: Diese Studie untersucht die Wechselwirkungen zwischen Amantadin und phasengetrennten Lipidmembranen und liefert Erkenntnisse über die Rolle von 1,2-Distearoyl-sn-Glycero-3-Phosphocholin in der Struktur und Funktion von Membranen (Kinnun et al., 2024).

  • Design of charge converting lipid nanoparticles via a microfluidic coating technique.: In dieser Studie werden Lipid-Nanopartikel mittels 1,2-Distearoyl-sn-Glycero-3-Phosphocholin mit Fähigkeiten zur Ladungsumwandlung generiert, wodurch Wirkstoffabgabesysteme verbessert werden können (Zöller et al., 2024).

  • Investigation and Comparison of Active and Passive Encapsulation Methods for Loading Proteins into Liposomes.: Diese Studie vergleicht Methoden zur Proteinverkapselung in Liposomen mittels 1,2-Distearoyl-sn-Glycero-3-Phosphocholin, was Fortschritte für Wirkstoffabgabetechnologien ermöglicht (Pisani et al., 2023).

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)


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Analysenzertifikate (COA)

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Mette Marie Bruun Nielsen et al.
Langmuir : the ACS journal of surfaces and colloids, 29(5), 1525-1532 (2013-01-04)
Imaging ellipsometry (IE) has been applied to generate laterally resolved thickness maps of spin-coated membranes in both the dry and fully hydrated state. Spin-coating offers a convenient preparation method for stacked supported membranes, and in-depth thickness maps for such films
Hiroyuki Nakamura et al.
Organic & biomolecular chemistry, 10(7), 1374-1380 (2011-12-24)
The fluorescence-labeled closo-dodecaborane lipid (FL-SBL) was synthesized from (S)-(+)-1,2-isopropylideneglycerol as a chiral starting material. FL-SBL was readily accumulated into the PEGylated DSPC liposomes prepared from DSPC, CH, and DSPE-PEG-OMe by the post insertion protocol. The boron concentrations and the fluorescent
Xiaoming Xu et al.
International journal of pharmaceutics, 423(2), 410-418 (2011-12-31)
A mathematical model has been developed to predict the encapsulation efficiency of hydrophilic drugs in unilamellar liposomes, and will be useful in formulation development to rapidly achieve optimized formulations. This model can also be used to compare drug encapsulation efficiencies
Shubhadeep Banerjee et al.
International journal of pharmaceutics, 436(1-2), 786-797 (2012-08-14)
pH-responsive polymers render liposomes pH-sensitive and facilitate the intracellular release of encapsulated payload by fusing with endovascular membranes under mildly acidic conditions found inside cellular endosomes. The present study reports the use of high-molecular weight poly(styrene-co-maleic acid) (SMA), which exhibits
Saumyabrata Mazumder et al.
PLoS neglected tropical diseases, 5(12), e1429-e1429 (2011-12-30)
Vaccines that activate strong specific Th1-predominant immune responses are critically needed for many intracellular pathogens, including Leishmania. The requirement for sustained and efficient vaccination against leishmaniasis is to formulate the best combination of immunopotentiating adjuvant with the stable antigen (Ag)

Questions

1–2 of 2 Questions  
  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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