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O0641

Sigma-Aldrich

Oroxylin A

≥98% (HPLC)

Synonym(e):

5,7-Dihydroxy-6-methoxy-2-phenyl-4H-1-benzopyran-4-on, 5,7-Dihydroxy-6-methoxyflavone, 6-Methoxybaicalein

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About This Item

Empirische Formel (Hill-System):
C16H12O5
CAS-Nummer:
480-11-5
Molekulargewicht:
284.26
MDL-Nummer:
MFCD02259441
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329818889

Assay

≥98% (HPLC)

Form

powder

Farbe

yellow

Löslichkeit

DMSO: ≥20 mg/mL

Lagertemp.

2-8°C

SMILES String

COc1c(O)cc2OC(=CC(=O)c2c1O)c3ccccc3

InChI

1S/C16H12O5/c1-20-16-11(18)8-13-14(15(16)19)10(17)7-12(21-13)9-5-3-2-4-6-9/h2-8,18-19H,1H3

InChIKey

LKOJGSWUMISDOF-UHFFFAOYSA-N

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Biochem./physiol. Wirkung

Oroxylin A is a flavonoid isolated from Scutellaria baicalensis, which is one of the most important medicinal herbs in traditional Korean/Chinese/Japanese medicine. It shows amelioration of Abeta(25-35) peptide-induced memory impairment.
Oroxylin A is a flavonoid isolated from Scutellaria baicalensis, which is one of the most important medicinal herbs in traditional Korean/Chinese/Japanese medicine. The amelioration of Abeta(25-35) peptide-induced memory impairment by oroxylin A is believed to be mediated via the GABAergic neurotransmitter system after a single administration, or by reductions in Abeta(25-35) peptide-induced astrocyte and microglia activations, iNOS expression, lipid peroxidation, and increased cholinergic neurotransmission after subchronic administration.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H302

Gefahreneinstufungen

Acute Tox. 4 Oral

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

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Analysenzertifikate (COA)

Lot/Batch Number
051M4605V
060M4608

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Tzu-Ling Tseng et al.
PloS one, 7(10), e47403-e47403 (2012-10-17)
Successful drug treatment for sepsis-related acute lung injury (ALI) remains a major clinical problem. This study was designed to assess the beneficial effects of post-treatment of oroxylin A (OroA), a flavonoid, in ameliorating lipopolysaccharides (LPS)-induced lung inflammation and fatality. Rats
Jingtian Qu et al.
Evidence-based complementary and alternative medicine : eCAM, 2020, 9257950-9257950 (2020-02-23)
Oroxylin A, a flavonoid, is naturally produced in many medicinal plants. Our previous study identified it as a phytoestrogen. Based on this, the present study investigated its vasoconstriction reducing effects and whether the action was mediated by the estrogen receptor
Se Jin Jeon et al.
Neuroscience research, 69(3), 214-222 (2010-12-15)
Oroxylin A (5,7-dihydroxy-6-methoxyfavone) is a flavonoid compound originated from the root of Scutellaria baicalensis Georgi. Our previous reports suggested that oroxylin A improves memory function in rat, at least in part, by its antagonistic effects on GABA(A) receptor. In addition
Min Xu et al.
Toxicology letters, 212(2), 113-125 (2012-05-23)
Hepatocellular carcinoma (HCC) is a refractory malignancy with a high incidence and large mortality. Current strategy for the chemotherapy of HCC focuses on developing agents with better efficacy and lower toxicity. In this study, we demonstrated that the natural flavonoid
Chenrui Li et al.
The AAPS journal, 14(1), 23-34 (2011-12-15)
Radix Scutellariae is a commonly used herbal medicine. Baicalein, wogonin, and oroxylin A are three major bioactive flavones in Radix Scutellariae and share similar chemical structures. The intestinal absorption and disposition of baicalein have been systematically investigated by our group
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